• Publications
  • Influence
Mechanism of the cardiotoxic actions of terfenadine.
OBJECTIVES AND METHODS To gain insight into possible mechanisms of and predisposing factors for torsades de pointes during terfenadine therapy, spontaneous reports in the US Food and DrugExpand
  • 642
  • 11
Glutamate and GABA-mediated synaptic currents in neurons of the rat dorsal motor nucleus of the vagus.
We report the presence of excitatory and inhibitory spontaneous and evoked synaptic currents in the dorsal motor nucleus of the vagus (DMV) in the rat upon vagal and perivagal stimulation. Whole cellExpand
  • 194
  • 11
Reversal of morphine-induced apnea in the anesthetized rat by drugs that activate 5-hydroxytryptamine(1A) receptors.
The purpose of our study was to test the hypothesis that 5-hydroxytryptamine (5-HT)(1A) receptor agonists counteract morphine-induced respiratory depression. Studies were conducted in anesthetizedExpand
  • 60
  • 9
  • PDF
Glucose effects on gastric motility and tone evoked from the rat dorsal vagal complex
1 To examine the effects of glucose on the central components of the vago‐vagal reflex control of gastric function, we performed both in vivo and in vitro experiments on neurones in the medialExpand
  • 75
  • 8
The role of the nervous system in the cardiovascular effects of digitalis.
  • 191
  • 4
Effect of activation of central nervous system serotonin 1A receptors on cardiorespiratory function.
Previous studies indicate that the new antihypertensive drug, urapidil, acts at the ventral surface of the medulla in cats to produce a fall in blood pressure. In addition, urapidil was found inExpand
  • 86
  • 4
Assessment of lower urinary tract functional deficit in rats with contusive spinal cord injury.
Traumatic spinal cord injury (SCI) produces lower urinary tract (LUT) dysfunction that has been studied in surgical transection models. Our aim was to assess LUT functional deficit in a clinicallyExpand
  • 51
  • 4
A reevaluation of the effects of stimulation of the dorsal motor nucleus of the vagus on gastric motility in the rat.
Our primary purpose was to characterize vagal pathways controlling gastric motility by microinjecting l-glutamate into the dorsal motor nucleus of the vagus (DMV) in the rat. An intragastric balloonExpand
  • 54
  • 4
  • PDF
CNS Site of Action and Brainstem Circuitry Responsible for the Intravenous Effects of Nicotine on Gastric Tone
The purposes of our study were to determine (1) the effects of intravenous (i.v.) nicotine on gastric mechanical function of anesthetized rats, (2) the CNS site of action of nicotine to produce theseExpand
  • 45
  • 4
  • PDF
GABA-mediated neurotransmission in the ventrolateral NTS plays a role in respiratory regulation in the rat.
Our purpose was to determine whether endogenously released GABA in the ventrolateral nucleus of the solitary tract (vlNTS) of the rat influences respiration. Experiments were carried out inExpand
  • 37
  • 4
  • PDF