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Drosophila Aurora B Kinase Is Required for Histone H3 Phosphorylation and Condensin Recruitment during Chromosome Condensation and to Organize the Central Spindle during Cytokinesis
Aurora/Ipl1-related kinases are a conserved family of enzymes that have multiple functions during mitotic progression. Although it has been possible to use conventional genetic analysis to dissect… Expand
Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules
Disruption of the function of the A-type Aurora kinase of Drosophila by mutation or RNAi leads to a reduction in the length of astral microtubules in syncytial embryos, larval neuroblasts, and… Expand
Genome-wide survey of protein kinases required for cell cycle progression
Cycles of protein phosphorylation are fundamental in regulating the progression of the eukaryotic cell through its division cycle. Here we test the complement of Drosophila protein kinases (kinome)… Expand
The Xenopus laevis Aurora-related Protein Kinase pEg2 Associates with and Phosphorylates the Kinesin-related Protein XlEg5*
- R. Giet, R. Uzbekov, F. Cubizolles, K. Le Guellec, C. Prigent
- Medicine, Biology
- The Journal of Biological Chemistry
- 21 May 1999
We have previously reported on the cloning of XlEg5, a Xenopus laevis kinesin-related protein from thebimC family (Le Guellec, R., Paris, J., Couturier, A., Roghi, C., and Philippe, M. (1991) Mol.… Expand
The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involved in bipolar mitotic spindle assembly.
By differential screening of a Xenopus laevis egg cDNA library, we have isolated a 2,111 bp cDNA which corresponds to a maternal mRNA specifically deadenylated after fertilisation. This cDNA, called… Expand
Aurora kinases, aneuploidy and cancer, a coincidence or a real link?
As Aurora kinases are overexpressed in a large number of cancers, and ectopic expression of Aurora generates polyploid cells containing multiple centrosomes, it has been tempting to suggest that… Expand
Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation
- Marc A. Schneider, He-Hsuan Hsiao, C. Will, R. Giet, H. Urlaub, R. Lührmann
- Medicine, Biology
- Nature Structural &Molecular Biology
- 1 February 2010
Reversible protein phosphorylation has an essential role during pre-mRNA splicing. Here we identify two previously unidentified phosphoproteins in the human spliceosomal B complex, namely the… Expand
Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases.
During the past five years, a growing number of serine-threonine kinases highly homologous to the Saccharomyces cerevisiae Ipl1p kinase have been isolated in various organisms. A Drosophila… Expand
PRP4 is a spindle assembly checkpoint protein required for MPS1, MAD1, and MAD2 localization to the kinetochores
- Emilie Montembault, S. Dutertre, C. Prigent, R. Giet
- Biology, Medicine
- The Journal of cell biology
- 19 November 2007
The spindle checkpoint delays anaphase onset until every chromosome kinetochore has been efficiently captured by the mitotic spindle microtubules. In this study, we report that the human… Expand
Drosophila Nek2 protein kinase knockdown leads to centrosome maturation defects while overexpression causes centrosome fragmentation and cytokinesis failure.
The Nima-related kinase 2 (Nek2) has been implicated in the regulation of centrosome integrity and separation in several species and is a candidate for cell transformation. We now show that reduction… Expand