R. Ghai

Publications47
h-index19
Citations1,141
Highly Influential Citations27
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Differential Structure‐Activity Relationships of Phosphoramidon Analogues for Inhibition of Three Metalloproteases: Endothelin‐Converting Enzyme, Neutral Endopeptidase, and Angiotensin‐Converting…
Summary: The structure-activity relationships of phosphoramidon analogues for inhibition of endothelin-converting enzyme (ECE), neutral endopeptidase 24.11 (NEP), and angiotensin-converting enzyme… Expand
Dicarboxylic acid dipeptide neutral endopeptidase inhibitors.
The synthesis of three series of dicarboxylic acid dipeptide neutral endopeptidase 24.11 (NEP) inhibitors is described. In particular, the amino butyramide 21a exhibited potent NEP inhibitory… Expand
Pharmacological profile of a non-peptidic dual inhibitor of neutral endopeptidase 24.11 and endothelin-converting enzyme.
CGS 26303 is a potent and structurally unique non-peptidic inhibitor of neutral endopeptidase (NEP) capable of protecting atrial natriuretic peptide (ANP) from enzymatic degradation. In addition, CGS… Expand
Occurrence of neutral endopeptidase activity in the cat carotid body and its significance in chemoreception
The carotid body contains both tachykinins and enkephalins. Neutral endopeptidase (NEP, E.C. 3.4.24.11), has been suggested to involve in the metabolism of these neuropeptides in several organs. In… Expand
New alpha-thiol dipeptide dual inhibitors of angiotensin-I converting enzyme and neutral endopeptidase EC 3.4.24.11.
Dual inhibitors of the two zinc metallopeptidases, neutral endopeptidase (NEP, EC 3.4.24.11) and angiotensin-I converting enzyme, have been the focus of much clinical interest for the treatment of… Expand
Disposition of thiorphan in DOCA-salt and spontaneously hypertensive rats.
Thiorphan was administered intravenously (i.v.) at 10 mg/kg to conscious rats in two different models of hypertension to allow a comparison of pharmacokinetics. The two models were: 1)… Expand
Structure and location of the O-glycosidic carbohydrate units of human chorionic gonadotropin.
The carbohydrate structure of the O-glycosidicallylinked oligosaccharide chains in P-subunit of human chorionic gonadotropin (hCG$) and their precise number and locations in the polypeptide chains… Expand
Identification of protease 3.4.24.11 as the major atrial natriuretic factor degrading enzyme in the rat kidney
We have identified a metalloendoprotease from rat kidney cortex that cleaves the cysteine-phenylalanine bond (Cys7-Phe8) within the 17 amino acid ring structure of atrial natriuretic factor (ANF).… Expand
Biochemical and immunological characterization of a histone variant associated with spermatogenesis in the mouse.
A chromosomal histone, H2S, specific to the mouse testis has been purified. Amino acid analysis indicated lack of cysteine and a high basic amino acid content typical of histones. Specific antibodies… Expand
Immunological properties of the beta-subunit of human chorionic gonadotropin. I. Effect of chemical and enzymatic modifications.
The beta-subunit of hCG (hCG beta) displays immunological cross-reactivity with human LH (hLH). A detailed study was undertaken to investigate the effect of chemical and enzymatic modifications on… Expand
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