• Publications
  • Influence
Processing of adenovirus 2-induced proteins.
Analysis of (35)S-methionine-labeled extracts of adenovirus 2-infected KB cells revealed 22 virus-induced polypeptide components. Most proteins of the virion were easily detected in extracts of wholeExpand
  • 221
  • 19
Deletion of Selenoprotein P Alters Distribution of Selenium in the Mouse*
Selenoprotein P (Se-P) contains most of the selenium in plasma. Its function is not known. Mice with the Se-P gene deleted (Sepp −/−) were generated. Two phenotypes were observed: 1) Sepp −/−miceExpand
  • 369
  • 18
Autoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizyme
Abstract Rat antizyme gene expression requires programmed, ribosomal frameshifting. A novel autoregulatory mechanism enables modulation of frameshifting according to the cellular concentrationExpand
  • 400
  • 15
The signal for a leaky UAG stop codon in several plant viruses includes the two downstream codons.
Expression of the RNA replicase domain of tobacco mosaic virus (TMV) and certain protein-coding regions in other plant viruses, is mediated by translational readthrough of a leaky UAG stop codon. ItExpand
  • 173
  • 14
A dual-luciferase reporter system for studying recoding signals.
A new reporter system has been developed for measuring translation coupling efficiency of recoding mechanisms such as frameshifting or readthrough. A recoding test sequence is cloned in between theExpand
  • 319
  • 11
Recoding: dynamic reprogramming of translation.
A minority of genes in probably all organisms rely on "recoding" for translation of their mRNAs. In these cases, the rules for decoding are temporarily altered through the action of specific signalsExpand
  • 312
  • 9
Sequence specificity of aminoglycoside‐induced stop codon readthrough: Potential implications for treatment of Duchenne muscular dystrophy
As a result of their ability to induce translational readthrough of stop codons, the aminoglycoside antibiotics are currently being tested for efficacy in the treatment of Duchenne muscular dystrophyExpand
  • 205
  • 8
Identification of sequence motifs in oligonucleotides whose presence is correlated with antisense activity.
Design of antisense oligonucleotides targeting any mRNA can be much more efficient when several activity-enhancing motifs are included and activity-decreasing motifs are avoided. This conclusion wasExpand
  • 64
  • 7
Recoding: translational bifurcations in gene expression.
During the expression of a certain genes standard decoding is over-ridden in a site or mRNA specific manner. This recoding occurs in response to special signals in mRNA and probably occurs in allExpand
  • 205
  • 6