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Mice Lacking Metabotropic Glutamate Receptor 5 Show Impaired Learning and Reduced CA1 Long-Term Potentiation (LTP) But Normal CA3 LTP
Class I metabotropic glutamate receptors (mGluRs) have been postulated to play a role in synaptic plasticity. To test the involvement of one member of this class, we have recently generated mutantExpand
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  • Open Access
Enhanced LTP in Mice Deficient in the AMPA Receptor GluR2
AMPA receptors (AMPARs) are not thought to be involved in the induction of long-term potentiation (LTP), but may be involved in its expression via second messenger pathways. However, one subunit ofExpand
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  • Open Access
Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype?
  • R. Gerlai
  • Biology, Medicine
  • Trends in Neurosciences
  • 1 May 1996
Gene targeting to create null mutations in mice is a powerful new tool in biology which will allow the molecular dissection of complex phenotypes such as mammalian brain function, and learning andExpand
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Zebrafish as an emerging model for studying complex brain disorders.
The zebrafish (Danio rerio) is rapidly becoming a popular model organism in pharmacogenetics and neuropharmacology. Both larval and adult zebrafish are currently used to increase our understanding ofExpand
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Towards a comprehensive catalog of zebrafish behavior 1.0 and beyond.
Zebrafish (Danio rerio) are rapidly gaining popularity in translational neuroscience and behavioral research. Physiological similarity to mammals, ease of genetic manipulations, sensitivity toExpand
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  • Open Access
Long-term behavioral changes in response to early developmental exposure to ethanol in zebrafish.
BACKGROUND Zebrafish is becoming an important research tool for the analysis of brain function and behavior. It has been proposed to model human alcoholism as well as fetal alcohol syndrome. PreviousExpand
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Impaired Cerebellar Synaptic Plasticity and Motor Performance in Mice Lacking the mGluR4 Subtype of Metabotropic Glutamate Receptor
The application of the glutamate analogl-2-amino-4-phosphonobutyric acid (l-AP4) to neurons produces a suppression of synaptic transmission. Althoughl-AP4 is a selective ligand at a subset ofExpand
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  • Open Access
Alarm substance induced behavioral responses in zebrafish (Danio rerio)
Zebrafish (zebra danio) are becoming increasingly popular in behavioral neuroscience and behavior genetics. This small vertebrate may be utilized in modeling human brain disorders. One of the majorExpand
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The social zebrafish: Behavioral responses to conspecific, heterospecific, and computer animated fish
Zebrafish has been in the forefront of developmental biology and genetics, but only recently has interest in their behavior increased. Zebrafish are small and prolific, which lends this species toExpand
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Zebrafish models for translational neuroscience research: from tank to bedside
The zebrafish (Danio rerio) is emerging as a new important species for studying mechanisms of brain function and dysfunction. Focusing on selected central nervous system (CNS) disorders (brainExpand
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