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Mice Lacking Metabotropic Glutamate Receptor 5 Show Impaired Learning and Reduced CA1 Long-Term Potentiation (LTP) But Normal CA3 LTP
Long-term potentiation (LTP) in mGluR5 mutants was significantly reduced in the NMDA receptor (NMDAR)-dependent pathways such as the CA1 region and dentate gyrus of the hippocampus, whereas LTP remained intact in the mossy fiber synapses on the CA3 region, an NMDAR-independent pathway.
Drinks like a fish: zebra fish (Danio rerio) as a behavior genetic model to study alcohol effects
Enhanced LTP in Mice Deficient in the AMPA Receptor GluR2
Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype?
- R. Gerlai
- BiologyTrends in Neurosciences
- 1 May 1996
Zebrafish as an emerging model for studying complex brain disorders.
Towards a comprehensive catalog of zebrafish behavior 1.0 and beyond.
A detailed catalog of zebrafish behaviors that covers both larval and adult models is developed, representing a beginning of creating a more comprehensive ethogram ofZebrafish behavior, which will improve interpretation of published findings, foster cross-species behavioral modeling, and encourage new groups to apply zebra fish neurobehavioral paradigms in their research.
Impaired Cerebellar Synaptic Plasticity and Motor Performance in Mice Lacking the mGluR4 Subtype of Metabotropic Glutamate Receptor
The results indicate that an important function of mGluR4 is to provide a presynaptic mechanism for maintaining synaptic efficacy during repetitive activation, and suggest that the presence ofmGLUR4 at the parallel fiber→Purkinje cell synapse is required for maintaining normal motor function.
Alarm substance induced behavioral responses in zebrafish (Danio rerio)
Myelination in the absence of myelin-associated glycoprotein
It is indicated that MAG is necessary for maintenance of the cytoplasmic collar and periaxonal space of myelinated fibres and not critical for myelin formation.
Long-term behavioral changes in response to early developmental exposure to ethanol in zebrafish.
- Yohaan Fernandes, R. Gerlai
- Medicine, PsychologyAlcoholism, clinical and experimental research
- 1 April 2009
The results suggest that zebrafish will be an appropriate model organism for the analysis of the effects of moderate to mild prenatal ethanol exposure.