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Methods for methanolysis of sphingolipids and direct determination of long-chain bases by gas chromatography
  • R. Gaver, C. Sweeley
  • Chemistry, Medicine
  • Journal of the American Oil Chemists' Society
  • 1 April 1965
A new, simple procedure is described for the direct gas chromatographic determination of sphingolipid bases as their trimethylsilyl derivatives. This method is used to study the nature of the mixtureExpand
High-performance liquid chromatographic procedure for the quantitative determination of paclitaxel (Taxol) in human plasma.
An isocratic high-performance liquid chromatographic method has been developed and validated for the quantitative determination of paclitaxel (Taxol), a novel antimitotic, anticancer agent, in humanExpand
High-performance liquid chromatographic procedures for the analysis of carboplatin in human plasma and urine
  • R. Gaver, G. Deeb
  • Chemistry, Medicine
  • Cancer Chemotherapy and Pharmacology
  • 2004
SummarySpecific, sensitive and reproducible high-performance liquid chromatographic procedures were developed for the quantitative analysis of carboplatin in human plasma and urine. Plasma and urineExpand
Disposition of parenteral butorphanol in man.
The metabolism and elimination of 3H-butorphanol (levo-3, 14-dihydroxy-N-(cyclobutylmethyl)[15-3H]morhinan) tartrate were determined in man after therapeutic im (2 mg) and iv (1 mg) doses. As judgedExpand
Human intravenous pharmacokinetics and absolute oral bioavailability of cefatrizine.
Cefatrizine was administered intravenously and orally at dose levels of 250, 500, and 1,000 mg to normal male volunteers in a crossover study. Intravenous pharmacokinetics were dose linear over thisExpand
The disposition of carboplatin in the beagle dog
SummaryCarboplatin was administered i.v. to four groups of three male beagle dogs at doses of 3, 6, 12, and 24 mg/kg (60–580 mg/m2). Plasma samples were obtained at appropriate times and protein-freeExpand
Disposition of anagrelide, an inhibitor of platelet aggregation
A single dose of 14C‐anagrelide (6,7‐dichloro‐1,5‐dihydroimidazo [2,1‐b] quinazolin‐2(3H)‐one monohydrochloride) equivalent to 1 mg free base and containing 100 µCi radioactivity, was taken by fiveExpand
Improved reagent for trimethylsilylation of sphingolipid bases.
This paper describes the trimethylsilylation of sphingolipid bases under conditions that give derivatives of improved stability. The retention times of the common C(18) and C(20) long-chain bases,Expand
Branched-chain sphingosines from Tetrahymena pyriformis.
Abstract In a previous paper (Carter et , al. , 1966) we reported the discovery of a branched-chain sphingolipid base (19-methyl-C20-phytosphingosine) in Crithidia fasciculata , a flagellatedExpand
Chemistry and metabolism of sphingolipids. 3-Oxo derivatives of N-acetylsphingosine and N-acetyldihydrosphingosine.
  • R. Gaver, C. Sweeley
  • Chemistry, Medicine
  • Journal of the American Chemical Society
  • 5 August 1966