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SR splicing factors serve as adapter proteins for TAP-dependent mRNA export.
SC35 autoregulates its expression by promoting splicing events that destabilize its mRNAs
It is shown that overexpression of SC35 in HeLa cells results in a significant decrease of endogenous SC35 mRNA levels along with changes in the relative abundance ofSC35 alternatively spliced mRNAs.
Sam68 sequestration and partial loss of function are associated with splicing alterations in FXTAS patients
It is reported that mRNAs containing expanded CGG repeats form large and dynamic intranuclear RNA aggregates that recruit several RNA‐binding proteins sequentially, first Sam68, then hnRNP‐G and MBNL1, and that tautomycin prevents both Sam68 and CGG RNA aggregate formation.
A Janus splicing regulatory element modulates HIV-1 tat and rev mRNA production by coordination of hnRNP A1 cooperative binding.
A novel family of plant splicing factors with a Zn knuckle motif: examination of RNA binding and splicing activities
Results show that atRSZp22 is a true plant splicing factor which combines structural and functional features of both h9G8 and hSRp20 and RNA binding assays to selected RNA sequences indicate an RNA binding specificity similar to the human splicing factors 9g8 and SRp20.
Differential Effects of the SR Proteins 9G8, SC35, ASF/SF2, and SRp40 on the Utilization of the A1 to A5 Splicing Sites of HIV-1 RNA*
This is the first investigation of the effects of variations of individual SR protein concentrations that is performed ex vivo on an RNA containing a complex set of splicing sites and shows by Western blot analysis that the Nef protein synthesis is strongly decreased by overexpression of SC35, SRp40, and ASF/SF2.
Roles of hnRNP A1, SR Proteins, and p68 Helicase in c-H-ras Alternative Splicing Regulation
- S. Guil, R. Gattoni, M. Carrascal, J. Abian, J. Stévenin, M. Bach-Elias
- BiologyMolecular and Cellular Biology
- 15 April 2003
The RNA-dependent helicase p68 is associated with both IDX and rasISS1 RNA, and suppression of p68 expression in HeLa cells by RNAi experiments results in a marked increase of IDX inclusion in the endogenous mRNA, suggesting a role for this protein in alternative splicing regulation.
Characterization and cloning of the human splicing factor 9G8: a novel 35 kDa factor of the serine/arginine protein family.
It is shown that a recombinant 9G8 protein, expressed using a baculovirus vector and excluding other SR factors, rescues the splicing activity of a9G8‐depleted nuclear extract and an S100 cytoplasmic fraction, indicating that 9G 8 plays a crucial role in splicing, similar to that of the other SR splicing factors.
The human hnRNP-M proteins: structure and relation with early heat shock-induced splicing arrest and chromosome mapping
These data suggest that these proteins are involved in splicing as well as in early stress-induced splicing arrest, and located the hnRNP-M encoding gene on human chromosome 19.
The 216-nucleotide intron of the E1A pre-mRNA contains a hairpin structure that permits utilization of unusually distant branch acceptors.
- K. Chébli, R. Gattoni, P. Schmitt, G. Hildwein, J. Stévenin
- Biology, ChemistryMolecular and cellular biology
- 1 November 1989
The results confirm the importance of the constraint of distance for the splicing reaction and show that this constraint may be overcome by means of a stable hairpin formation.