• Publications
  • Influence
The proximal origin of SARS-CoV-2
It is shown that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus, and scenarios by which they could have arisen are discussed. Expand
Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak
This West African variant likely diverged from central African lineages around 2004, crossed from Guinea to Sierra Leone in May 2014, and has exhibited sustained human-to-human transmission subsequently, with no evidence of additional zoonotic sources. Expand
Clinical illness and outcomes in patients with Ebola in Sierra Leone.
The incubation period and case fatality rate among patients with EVD in Sierra Leone are similar to those observed elsewhere in the 2014 outbreak and in previous outbreaks. Expand
A general model for the transmembrane proteins of HIV and other retroviruses.
A hypothetical model of the transmembrane (TM) protein of human immunodeficiency virus (HIV) is proposed that is derived from the known structure of the influenza TM protein HA2. This model isExpand
Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus
It is shown that whereas the 2013-2015 EVD epidemic is fueled by human- to-human transmissions, LASV infections mainly result from reservoir-to-human infections. Expand
Virus genomes reveal factors that spread and sustained the Ebola epidemic
It is revealed that this large epidemic was a heterogeneous and spatially dissociated collection of transmission clusters of varying size, duration and connectivity, which will help to inform interventions in future epidemics. Expand
Enabling the genomic revolution in Africa
If the dearth of genomics research involving Africans persists, the potential health and economic benefits emanating from genomic science may elude an entire continent. Expand
Ebola Virus Epidemiology, Transmission, and Evolution during Seven Months in Sierra Leone
Analysis of sequences from 232 patients sampled over 7 months in Sierra Leone, along with 86 previously released genomes from earlier in the epidemic, confirms sustained human-to-human transmission within Sierra Leone and finds no evidence for import or export of EBOV across national borders after its initial introduction. Expand
Peptide inhibitors of dengue virus and West Nile virus infectivity
The inhibitory peptides identified here can serve as lead compounds for the development of peptide drugs for flavivirus infection and are suggested to be noncytotoxic and act in a sequence specific manner. Expand
Genomic epidemiology reveals multiple introductions of Zika virus into the United States
It is shown that at least 4 introductions, but potentially as many as 40, contributed to the outbreak in Florida and that local transmission is likely to have started in the spring of 2016—several months before its initial detection. Expand