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The proximal origin of SARS-CoV-2
SARS-CoV-2 is the seventh coronavirus known to infect humans; SARSCoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here weExpand
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Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak
In its largest outbreak, Ebola virus disease is spreading through Guinea, Liberia, Sierra Leone, and Nigeria. We sequenced 99 Ebola virus genomes from 78 patients in Sierra Leone to ~2000× coverage.Expand
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Clinical illness and outcomes in patients with Ebola in Sierra Leone.
BACKGROUND Limited clinical and laboratory data are available on patients with Ebola virus disease (EVD). The Kenema Government Hospital in Sierra Leone, which had an existing infrastructure forExpand
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Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus
The 2013-2015 West African epidemic of Ebola virus disease (EVD) reminds us of how little is known about biosafety level 4 viruses. Like Ebola virus, Lassa virus (LASV) can cause hemorrhagic feverExpand
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Peptide inhibitors of dengue virus and West Nile virus infectivity
Viral fusion proteins mediate cell entry by undergoing a series of conformational changes that result in virion-target cell membrane fusion. Class I viral fusion proteins, such as those encoded byExpand
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Virus genomes reveal factors that spread and sustained the Ebola epidemic
TLDR
We reconstruct the dispersal, proliferation and decline of Ebola virus throughout the region by analysing 1,610 Ebola virus genomes, which represent over 5% of the known cases. Expand
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A general model for the transmembrane proteins of HIV and other retroviruses.
A hypothetical model of the transmembrane (TM) protein of human immunodeficiency virus (HIV) is proposed that is derived from the known structure of the influenza TM protein HA2. This model isExpand
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Structural basis for antibody-mediated neutralization of Lassa virus
The crystal structure of an antibody–viral glycoprotein complex illuminates viral entry mechanisms and provides a blueprint for vaccine design. A step on the path to a Lassa vaccine Lassa fever is aExpand
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Enabling the genomic revolution in Africa
H3Africa is developing capacity for health-related genomics research in Africa Our understanding of genome biology, genomics, and disease, and even human history, has advanced tremendously with theExpand
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Ebola Virus Epidemiology, Transmission, and Evolution during Seven Months in Sierra Leone
Summary The 2013–2015 Ebola virus disease (EVD) epidemic is caused by the Makona variant of Ebola virus (EBOV). Early in the epidemic, genome sequencing provided insights into virus evolution andExpand
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