Genetic studies of body mass index yield new insights for obesity biology
- A. Locke, Bratati Kahali, E. Speliotes
- BiologyNature
- 11 February 2015
A genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals provide strong support for a role of the central nervous system in obesity susceptibility.
The definition, classification, and prognosis of chronic kidney disease: a KDIGO Controversies Conference report.
- A. Levey, P. D. de Jong, K. Eckardt
- MedicineKidney International
- 1 July 2011
KDIGO has convened a workgroup to develop a global clinical practice guideline for the definition, classification, and prognosis of chronic kidney disease.
Defining the role of common variation in the genomic and biological architecture of adult human height
- A. Wood, T. Esko, T. Frayling
- BiologyNature Genetics
- 8 September 2014
The results indicate a genetic architecture for human height that is characterized by a very large but finite number of causal variants, including mTOR, osteoglycin and binding of hyaluronic acid.
Chronic kidney disease and cardiovascular risk: epidemiology, mechanisms, and prevention
- R. Gansevoort, R. Correa-Rotter, C. Wen
- Medicine, BiologyThe Lancet
- 27 July 2013
Tolvaptan in patients with autosomal dominant polycystic kidney disease.
- V. Torres, A. Chapman, F. Czerwiec
- MedicineNew England Journal of Medicine
- 20 December 2012
Tolvaptan, as compared with placebo, slowed the increase in total kidney volume and the decline in kidney function over a 3-year period in patients with ADPKD but was associated with a higher discontinuation rate, owing to adverse events.
New genetic loci link adipose and insulin biology to body fat distribution
- D. Shungin, T. Winkler, K. Mohlke
- BiologyNature
- 16 December 2014
A genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis
- K. Matsushita, Marije van der Velde, R. Gansevoort
- MedicineThe Lancet
- 12 June 2010
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013: a systematic…
- M. Forouzanfar, Lily T Alexander, C. Murray
- MedicineThe Lancet
- 10 September 2015
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013: a systematic…
- M. Forouzanfar, Lily T Alexander, C. Murray
- Medicine, Political ScienceBDJ
- 2015
The challenge for governments and the health development community more broadly is to heed knowledge about the comparative effect of health risks, according to the World Health Organization.
Decline in estimated glomerular filtration rate and subsequent risk of end-stage renal disease and mortality.
Declines in estimated GFR smaller than a doubling of serum creatinine concentration occurred more commonly and were strongly and consistently associated with the risk of ESRD and mortality, supporting consideration of lesser declines in Estimated GFR (such as a 30% reduction over 2 years) as an alternative end point for CKD progression.
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