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Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
TLDR
The data support a link between TLRs and vitamin D–mediated innate immunity and suggest that differences in ability of human populations to produce vitamin D may contribute to susceptibility to microbial infection. Expand
The 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D From the Institute of Medicine: What Clinicians Need to Know
TLDR
Prevalence of vitamin D deficiency in North America has been overestimated; the data show that almost all individuals in this population meet their RDA for vitamin D. Expand
The 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D from the Institute of Medicine: What Clinicians Need to Know
TLDR
The Committee concluded that the prevalence of vitamin D inadequacy in North America has been overestimated and urgent research and clinical priorities were identified, including reassessment of laboratory ranges for 25-hydroxyvitamin D, to avoid problems of both undertreatment and overtreatment. Expand
Endogenous antimicrobial peptides and skin infections in atopic dermatitis.
TLDR
A deficiency in the expression of antimicrobial peptides may account for the susceptibility of patients with atopic dermatitis to skin infection with S. aureus. Expand
HIF-1alpha expression regulates the bactericidal capacity of phagocytes.
TLDR
HIF-1alpha was induced by bacterial infection, even under normoxia, and regulated the production of key immune effector molecules, including granule proteases, antimicrobial peptides, nitric oxide, and TNF-alpha. Expand
Biology of the syndecans: a family of transmembrane heparan sulfate proteoglycans.
Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea
TLDR
The role of cathelicidin in skin inflammatory responses is confirmed and an explanation for the pathogenesis of rosacea is suggested by demonstrating that an exacerbated innate immune response can reproduce elements of this disease. Expand
AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense.
TLDR
AMPs are multifunctional molecules that have a central role in infection and inflammation and complement their antimicrobial action and favor resolution of infection and repair of damaged epithelia. Expand
Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism.
TLDR
What is believed to be a previously unexpected role for vitamin D3 in innate immunity is demonstrated, enabling keratinocytes to recognize and respond to microbes and to protect wounds against infection. Expand
Innate antimicrobial peptide protects the skin from invasive bacterial infection
TLDR
It is shown that cathelicidins are an important native component of innate host defence in mice and provide protection against necrotic skin infection caused by Group A Streptococcus (GAS). Expand
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