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Drusen proteome analysis: An approach to the etiology of age-related macular degeneration
Data strongly support the hypothesis that oxidative injury contributes to the pathogenesis of AMD and suggest that oxidative protein modifications may have a critical role in drusen formation. Expand
NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components
It is shown that drusen isolated from donor AMD eyes activates the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome, causing secretion of interleukin-1β (IL-1 β) and IL-18, which indicates a protective role for NLRP3 andIL-18 in the progression of AMD. Expand
Structural Identification by Mass Spectrometry of Oxidized Phospholipids in Minimally Oxidized Low Density Lipoprotein That Induce Monocyte/Endothelial Interactions and Evidence for Their Presence in
  • Andrew D. Watson, Norbert Leitinger, +10 authors Judith A. Berliner
  • Chemistry, Medicine
  • The Journal of Biological Chemistry
  • 23 May 1997
Two of three molecules present in MM-LDL and Ox-PAPC that induce monocyte-endothelial interactions are determined and suggest that specific oxidized derivatives of arachidonic acid-containing phospholipids may be important initiators of atherogenesis. Expand
Oxidative damage–induced inflammation initiates age-related macular degeneration
It is hypothesized that these mice are sensitized to the generation of carboxyethylpyrrole adducts in the outer retina, where docosahexaenoic acid is abundant and conditions for oxidative damage are permissive, and provides a platform for dissecting the molecular pathology of oxidative damage in theouter retina and the immune response contributing to AMD. Expand
Identification of a Novel Family of Oxidized Phospholipids That Serve as Ligands for the Macrophage Scavenger Receptor CD36*
The structural characteristics required for high affinity binding of oxidized PC species to CD36 are a phospholipid with an sn-2 acyl group that incorporates a terminal γ-hydroxy(or oxo)-β-unsaturated carbonyl (oxPCCD36). Expand
Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype
Using multiple mouse in vivo thrombosis models, it is demonstrated that genetic deletion of Cd36 protects mice from hyperlipidemia-associated enhanced platelet reactivity and the accompanying prothrombotic phenotype. Expand
Carboxyethylpyrrole Protein Adducts and Autoantibodies, Biomarkers for Age-related Macular Degeneration*
Results suggest that together CEP immunoreactivity and autoantibody titer may have diagnostic utility in predicting AMD susceptibility. Expand
4‐Hydroxynonenal‐Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease
The known neurotoxicity of HNE suggests that lipid peroxidation may also play a role in the neuronal death in AD that underlies cognitive deficits. Expand
Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands
These findings establish a new function of TLR2 as a sensor of oxidation-associated molecular patterns, providing a key link connecting inflammation, oxidative stress, innate immunity and angiogenesis. Expand
Proteomic approaches to understanding age-related macular degeneration.
Western blot analysis suggests that carboxyethyl pyrrole-protein adducts derived from docosahexaenoate-containing lipids are more abundant in AMD than in normal tissues, and may be causally involved in drusen formation and Bruch's membrane thickening. Expand