• Publications
  • Influence
Molecular pathways in cancer-related inflammation.
Accumulating evidence shows that chronic inflammation is associated to increased risk of cancer. An inflammatory component is present also in the microenvironment of tumours epidemiologicallyExpand
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Microenvironment drug resistance in multiple myeloma: emerging new players
Multiple myeloma (MM) drug resistance (DR) is a multistep transformation process based on a powerful interplay between bone marrow stromal cells and MM cells that allows the latter to escapeExpand
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  • Open Access
Neutrophil recruitment and airway epithelial cell involvement in chronic cystic fibrosis lung disease.
The pathological hallmark of cystic fibrosis (CF) chronic inflammatory response is the massive neutrophil influx into the airways. This dysregulated neutrophil emigration may be caused by theExpand
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Sulfide enhancement of PMN apoptosis.
Hydrogen sulfide is a toxic metabolite released by several bacterial agents under anaerobic conditions. In the present paper, we investigated the effects of sulfide on polymorphonuclear cell (PMN)Expand
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Halting pro-survival autophagy by TGFβ inhibition in bone marrow fibroblasts overcomes bortezomib resistance in multiple myeloma patients
Bortezomib (bort) has improved overall survival in patients with multiple myeloma (MM), but the majority of them develop drug resistance. In this study, we demonstrate that bone marrow (BM)Expand
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Enhancement of Fibroblast Proliferation, Collagen Biosynthesis and Production of Growth Factors as a Result of Combining Sodium Hyaluronate and Aminoacids
Fibroblasts play a key role in tissue healing by producing the majority of extracellular matrix components, favouring granulation tissue formation, and stimulating re-epithelialization. Hyaluronan isExpand
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Downregulation of human polymorphonuclear cell activities exerted by microorganisms belonging to the alpha-2 subgroup of Proteobacteria (Afipia felis and Rochalimaea henselae).
Intracellular pathogens have evolved effective mechanisms in order to survive in an intracellular environment, thus avoiding destruction by phagocytic cells. In this regard, a correlation betweenExpand
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In Vitro Effects of Polyamines on Polymorphonuclear Cell Apoptosis and Implications in the Pathogenesis of Periodontal Disease
Apoptosis provides a mechanism for clearance of unwanted cells in a variety of situations in which programmed or physiological cell death occurs; but the premature death of defensive cells couldExpand
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Studies on stimulus-response coupling in human neutrophils. I. Role of monovalent cations in the respiratory and secretory response to N-formylmethionylleucylphenylalanine.
Abstract Human blood neutrophils suspended in Na+-free, high-K+, phosphate-buffered solution exhibit respiratory and secretory responses to N-formylmethionylleucylphenylalanine (fMet-Leu-Phe) muchExpand
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  • Open Access
Bone marrow fibroblasts parallel multiple myeloma progression in patients and mice: in vitro and in vivo studies
The role of cancer-associated fibroblasts (CAFs) has not been previously studied in multiple myeloma (MM). Here, cytofluorimetric analysis revealed higher proportions of bone marrow (BM) CAFs inExpand
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