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An investigation of the potential effect of vacuoles in human sperm on DNA damage using a chromosome assay and the TUNEL assay.
The results showed that large vacuoles were not responsible for DNA damage, suggesting that intra-cytoplasmic injection of morphologically selected sperm may not be required for patients who produce high-quality semen. Expand
Uterine and circulating natural killer cells and their roles in women with recurrent pregnancy loss, implantation failure and preeclampsia.
The lower expression of NKp46(+) NK cells in women with preeclampsia may account for the higher production of NK1 cytokines - known as the NK1 shift - in pregnant women with predisposition to reproductive failure. Expand
Frontal brain activation in premature infants' response to auditory stimuli in neonatal intensive care unit.
The results showed that the premature infants reacted differently to the different voice stimuli, and it is presumed that both mothers' and nurses' voices represent positive stimuli for premature infants because both activate the frontal brain. Expand
Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection
Autosomal recessive, partial DBR1 deficiency underlies viral infection of the brainstem in humans through the disruption of tissue-specific and cell-intrinsic immunity to viruses. Expand
Changes of NK Cells in Preeclampsia
Various expressions of NK cell surface markers including NCRs on NK cells, NK cell cytotoxicity, and production of cytokines and angiogenic factors by NK cells were reviewed in relation to preeclampsia. Expand
Expression of Natural Cytotoxicity Receptors on Peritoneal Fluid Natural Killer Cell and Cytokine Production by Peritoneal Fluid Natural Killer Cell in Women with Endometriosis
To investigate the relationship between the expression of natural cytotoxicity receptors (NCRs) on peritoneal fluid (PF) natural killer (NK) (pfNK) cells and cytokine production by pfNK cells inExpand
Clinical Characteristics of Perinatal Lethal Hypophosphatasia: A Report of 6 Cases
Although a good genotype-phenotype correlation has been reported in hypophosphatasia, the genotype alone does not always predict the life span of the patients, and these cases suggested the importance of genetic counseling. Expand
A novel mutation p.Ser348Cys in FGFR3 causes achondroplasia
A Novel Mutation p.Ser348Cys in FGFR3 Causes Achondroplasia Kosei Hasegawa,* Rie Fukuhara, Tadashi Moriwake, Hiroyuki Tanaka, Yousuke Higuchi, Miho Yamashita, and Hirokazu Tsukahara Department ofExpand
Erythrocytes counteract the negative effects of female ageing on mouse preimplantation embryo development and blastocyst formation.
BACKGROUND The low developmental competence of embryos from ageing females remains an enigma; it is presumably attributable to oxidative stress. A number of antioxidant mechanisms exist in theExpand
Retinoic acid-inducible gene-I is induced by interferon-gamma and regulates CXCL11 expression in HeLa cells.
It is demonstrated that IFN-gamma stimulates endometrial epithelial cells to produce CXCL11, which is implicated in implantation and pregnancy and RNA interference against RIG-I resulted in the suppression of the IFN -gamma-induced CXCl11 expression. Expand