Touch, sound and vision in human superior temporal sulcus
Environmental toxicants and autism spectrum disorders: a systematic review
- D. Rossignol, S. Genuis, R. Frye
- Psychology, Environmental ScienceTranslational Psychiatry
- 1 February 2014
The findings of this review suggest that the etiology of ASD may involve, at least in a subset of children, complex interactions between genetic factors and certain environmental toxicants that may act synergistically or in parallel during critical periods of neurodevelopment, in a manner that increases the likelihood of developing ASD.
Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain
Results indicate that decreased GSH/GSSG redox/antioxidant capacity and increased oxidative stress in the autism brain may have functional consequence in terms of a chronic inflammatory response, increased mitochondrial superoxide production, and oxidative protein and DNA damage.
Melatonin in autism spectrum disorders: a systematic review and meta‐analysis
Melatonin‐related findings in autism spectrum disorders (ASD) are investigated, including autistic disorder, Asperger syndrome, Rett syndrome, and pervasive developmental disorders.
Primary Mitochondrial Disease and Secondary Mitochondrial Dysfunction: Importance of Distinction for Diagnosis and Treatment
Differentiation between PMD and SMD has been crucial for diagnosis and treatment and rapid advances in molecular testing, made possible by next generation sequencing, have been effective at least in some cases in establishing accurate diagnoses.
High Rate of Recurrent De Novo Mutations in Developmental and Epileptic Encephalopathies.
Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review
Mitochondrial Dysfunction Can Connect the Diverse Medical Symptoms Associated With Autism Spectrum Disorders
New understanding of ASD should provide researchers a pathway for understanding the etiopathogenesis of ASD and clinicians the potential to develop medical therapies, and how mitochondrial dysfunction can bridge the gap for understanding how these seemingly disparate medical conditions are related.
Surface area accounts for the relation of gray matter volume to reading-related skills and history of dyslexia.
- R. Frye, J. Liederman, Benjamin Malmberg, J. Mclean, David Strickland, M. Beauchamp
- Psychology, BiologyCerebral Cortex
- 1 November 2010
Cortical surface area reflects cortical folding patterns determined prenatally, this suggests that brain differences in dyslexia are rooted in early cortical development and are not due to compensatory changes that occur during postnatal development and would be expected to influence cortical thickness.
Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism
The evidence linking oxidative stress, mitochondrial dysfunction and immune dysregulation/inflammation in the brain of ASD individuals is examined, suggesting that ASD has a clear biological basis with features of known medical disorders.