R. Frye

Publications237
h-index47
Citations7,750
Highly Influential Citations219
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Touch, sound and vision in human superior temporal sulcus
TLDR
It is concluded that STSms is important for integrating information from the somatosensory as well as the auditory and visual modalities, and could be the human homolog of macaque STP. Expand
Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain
TLDR
Results indicate that decreased GSH/GSSG redox/antioxidant capacity and increased oxidative stress in the autism brain may have functional consequence in terms of a chronic inflammatory response, increased mitochondrial superoxide production, and oxidative protein and DNA damage. Expand
Environmental toxicants and autism spectrum disorders: a systematic review
TLDR
The findings of this review suggest that the etiology of ASD may involve, at least in a subset of children, complex interactions between genetic factors and certain environmental toxicants that may act synergistically or in parallel during critical periods of neurodevelopment, in a manner that increases the likelihood of developing ASD. Expand
Internal consistency reliability of the fractionated and whole University of Pennsylvania Smell Identification Test
TLDR
Results indicate that the UPSIT and its 10-, 20-, and 30-item fragments have very high ICRs and individual UPSIT booklets or their combinations can be used to assess smell function in a reliable manner where extreme time constraints are present (e.g., in surveys and in brief neuropsychological test batteries). Expand
Mitochondrial Dysfunction Can Connect the Diverse Medical Symptoms Associated With Autism Spectrum Disorders
TLDR
New understanding of ASD should provide researchers a pathway for understanding the etiopathogenesis of ASD and clinicians the potential to develop medical therapies, and how mitochondrial dysfunction can bridge the gap for understanding how these seemingly disparate medical conditions are related. Expand
Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review
N-acetylcysteine (NAC) is recognized for its role in acetaminophen overdose and as a mucolytic. Over the past decade, there has been growing evidence for the use of NAC in treating psychiatric and… Expand
Dose-related effects of cigarette smoking on olfactory function.
TLDR
It is suggested that smoking causes long-term but reversible adverse effects on the ability to smell and the failure of some studies to demonstrate smoking effects may be caused by the inclusion of persons with a history of smoking in the nonsmoking groups. Expand
Surface area accounts for the relation of gray matter volume to reading-related skills and history of dyslexia.
TLDR
Cortical surface area reflects cortical folding patterns determined prenatally, this suggests that brain differences in dyslexia are rooted in early cortical development and are not due to compensatory changes that occur during postnatal development and would be expected to influence cortical thickness. Expand
Melatonin in autism spectrum disorders: a systematic review and meta‐analysis
  • D. Rossignol, R. Frye
  • Psychology, Medicine
  • Developmental medicine and child neurology
  • 1 September 2011
TLDR
Melatonin‐related findings in autism spectrum disorders (ASD) are investigated, including autistic disorder, Asperger syndrome, Rett syndrome, and pervasive developmental disorders. Expand
Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism
TLDR
The evidence linking oxidative stress, mitochondrial dysfunction and immune dysregulation/inflammation in the brain of ASD individuals is examined, suggesting that ASD has a clear biological basis with features of known medical disorders. Expand
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