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Fluence-based relative biological effectiveness for charged particle carcinogenesis in mouse Harderian gland.
- E. Alpen, P. Powers-Risius, S. Curtis, R. DeGuzman, R. Fry
- Chemistry, Medicine
- Advances in space research : the official journal…
- 1 October 1994
Neoplasia in the rodent Harderian gland has been used to determine the carcinogenic potential of irradiation by HZE particles, and an analysis of the probabilities of ion traversals of the nucleus has shown that for these high stopping powers that a single hit is effective in producing neoplastic transformation. Expand
High-LET radiation carcinogenesis.
Limiting values of RBEs for the induction of cancer in various tissues can be determined, but it will require sufficient data obtained at low single doses or with small fractions to be determined. Expand
Extrapolation of the relative risk of radiogenic neoplasms across mouse strains and to man.
It was found that the relative risk estimates for lung, breast, and leukemia were not significantly different between humans and mice, and in the case of liver tumors, mice had a higher risk than humans. Expand
Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene.
Summary The effects of dietary phenobarbital on hepatocarcinogenesis in rats fed 2-acetylaminofluorene (AAF) were studied. The simultaneous feeding of AAF and phenobarbital reduced the… Expand
Health effects research in oil shale development
The data obtained in the lung adenoma bioassay suggest that Crude Shale Oil has tumorigenic potential andHydrotreatment of the shale oil abolished the detectable mutagenic activity and also reduced the cytotoxicity as measured in cellular systems. Expand
Comparative enhancing effects of phenobarbital, amobarbital, diphenylhydantoin, and dichlorodiphenyltrichloroethane on 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat.
The results show that the sequential treatment technique readily distinguishes among substances differing in enhancing ability and should prove useful in screening additional substances for this activity, and shows that Phenobarbital and DDT selectively increased the incidence of highly differentiated tumors throughout most of the experiment. Expand
Enhancing effects of phenobarbitone and butylated hydroxytoluene on 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat.
- C. Peraino, R. Fry, E. Staffeldt, J. Christopher
- Chemistry, Medicine
- Food and cosmetics toxicology
The results suggest that the dissimilar tumorigenic-enhancing abilities of BHT and phenobarbitone may result from differences in the effects of these agents on biochemical processes related to liver growth. Expand
Comparison of Gen-Probe DNA probe test and culture for the detection of Neisseria gonorrhoeae in endocervical specimens
- E. Panke, L. I. Yang, P. Leist, P. Magevney, R. Fry, R. Lee
- Journal of clinical microbiology
- 1 May 1991
The study indicated that with the modification of the manufacturer's endpoint interpretation, the DNA probe test was essentially equivalent to the culture method in terms of sensitivity, specificity, and positive and negative predictive values in both symptomatic and asymptomatic patient populations. Expand
Comparison of intestine and bone marrow radiosensitivity of the BALB/c and the C57BL/6 mouse strains and their B6CF1 offspring.
- W. Hanson, R. Fry, A. Sallese, H. Frischer, T. Ahmad, E. J. Ainsworth
- Biology, Medicine
- Radiation research
- 1 June 1987
The more rapid recovery in intestinal epihelial cell production in the B6CF1 hybrid after irradiation may provide an increased mucosal barrier and may, in part, explain the difference in the response to radiation compared to that in the BALB/c. Expand
On the shape of neutron dose-effect curves for radiogenic cancers and life shortening in mice
The conclusions were that for life shortening and most radiogenic cancers, the dose-effect curves are linear and that fractionation of the neutron dose has no effect on the magnitude of the response of equal total doses over the range of doses studied. Expand