R. Frussa-Filho

Publications213
h-index39
Citations4,220
Highly Influential Citations111
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Resistance to ethanol sensitization is associated with increased NMDA receptor binding in specific brain areas.
Co-administration of N-methyl-D-aspartate (NMDA) receptor antagonists is known to block the development of behavioral sensitization to ethanol and other psychostimulants. Since ethanol sensitization… Expand
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Mitochondrial calcium, oxidative stress and apoptosis in a neurodegenerative disease model induced by 3‐nitropropionic acid
Intracellular calcium homeostasis is important for cell survival. However, increase in mitochondrial calcium (Ca2+m) induces opening of permeability transition pore (PTP), mitochondrial dysfunction… Expand
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Vitamin E attenuates reserpine-induced oral dyskinesia and striatal oxidized glutathione/reduced glutathione ratio (GSSG/GSH) enhancement in rats
The effects of a previous and concomitant treatment with vitamin E (VE) were studied on an animal model of tardive dyskinesia, i.e., the frequency of spontaneous tongue protrusions in rats treated… Expand
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Anxiogenic effect of sleep deprivation in the elevated plus-maze test in mice
RationaleSeveral clinical studies demonstrate that the absence of periods of sleep is closely related to occurrence of anxiety symptoms. However, the basis of these interactions is poorly understood.… Expand
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The neurotensin receptor antagonist, SR48692, attenuates the expression of amphetamine-induced behavioural sensitisation in mice.
The effects of acute administration of the neurotensin receptor antagonist, SR48692 (2-[[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-carbonyl]amino]adamantane-2-carboxylic acid),… Expand
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Neuroleptic drugs revert the contextual fear conditioning deficit presented by spontaneously hypertensive rats: a potential animal model of emotional context processing in schizophrenia?
Schizophrenia, bipolar disorder, and attention deficit/hyperactivity disorder (ADHD) present abnormalities in emotion processing. A previous study showed that the spontaneously hypertensive rats… Expand
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Addictive potential of modafinil and cross‐sensitization with cocaine: a pre‐clinical study
Repeated or even a single exposure to drugs of abuse can lead to persistent locomotor sensitization, which is the result of an abundance of neuroplastic changes occurring within the circuitry… Expand
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Adolescent mice are more vulnerable than adults to single injection-induced behavioral sensitization to amphetamine
Drug-induced behavioral sensitization in rodents has enhanced our understanding of why drugs acquire increasing motivational and incentive value. Compared to adults, human adolescents have… Expand
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Effects of buspirone on an animal model of tardive Dyskinesia
1. The effects of buspirone were studied on an animal model of tardive dyskinesia, i.e., the quantification of orofacial dyskinesia in rats repeatedly treated with reserpine. 2. Rats were co-treated… Expand
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PRECLINICAL STUDY: Long‐term haloperidol treatment (but not risperidone) enhances addiction‐related behaviors in mice: role of dopamine D2 receptors
The high prevalence of psychostimulant abuse observed in schizophrenic patients may be related to the development of mesolimbic dopaminergic supersensitivity (MDS) or nigrostriatal dopaminergic… Expand
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