R. Friedlander

Publications297
h-index59
Citations15,712
Highly Influential Citations586
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Neurotoxicity induces cleavage of p35 to p25 by calpain
TLDR
Observations indicate that cleavage of p35 to p25 by calpain may be involved in the pathogenesis of Alzheimer's disease.
Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease
TLDR
It is reported that minocycline delays disease progression, inhibits casp enzyme-1 and caspase-3 mRNA upregulation, and decreases inducible nitric oxide synthetase activity, in the R6/2 mouse model of Huntington disease.
Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice
TLDR
It is found that minocycline inhibits mitochondrial permeability-transition-mediated cytochrome c release, and this drug may be a novel therapy for ALS.
Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model.
TLDR
Caspases play an instrumental role in neurodegeneration in transgenic mSOD1(G93A) mice, which suggests that caspase inhibition may have a protective role in ALS.
Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease
TLDR
It is shown that minocycline is a drug that directly inhibits both caspase-independent and -dependent mitochondrial cell death pathways, and the mechanism by which minocyCline mediates its remarkably broad neuroprotective effects is delineated.
Transcranial focused ultrasound modulates the activity of primary somatosensory cortex in humans.
TLDR
Functional investigations revealed that tFUS targeted to somatosensory cortex significantly enhanced discrimination of pins at closer distances as well as frequency of air puffs, without affecting response bias or task attention, and neuromodulating influence and spatial resolution were assessed.
Apoptosis and caspases in neurodegenerative diseases.
TLDR
Pharmacologic interference with the induction or completion of apoptosis holds promise for the treatment of neurodegenerative diseases, and clinical trials with one such agent are already under way.
Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease
TLDR
Evidence of caspase-1 activation in the brains of mice and humans with Huntington's disease is demonstrated and it is demonstrated that intracerebroventricular administration of a casp enzyme inhibitor delays disease progression and mortality in the mouse model of Huntington’s disease.
Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage.
TLDR
Z-VAD.FMK protected against alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate-induced or to a lesser extent N- methyl-D-aspartate- induced excitotoxic brain damage and provided therapeutic targets for stroke and neurodegenerative brain damage.
Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury.
TLDR
Investigation of permeability transition-mediated release of mitochondrial cytochrome c in rats suggested that minocycline treatment alleviated later-phase tissue loss, with significant sparing of white matter and ventral horn motoneurons at levels adjacent to the epicenter.
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