R. Freynhagen

Publications108
h-index35
Citations5,618
Highly Influential Citations241
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painDETECT: a new screening questionnaire to identify neuropathic components in patients with back pain
ABSTRACT Objective: Nociceptive and neuropathic components both contribute to pain. Since these components require different pain management strategies, correct pain diagnosis before and during… Expand
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  • 109
Efficacy of pregabalin in neuropathic pain evaluated in a 12-week, randomised, double-blind, multicentre, placebo-controlled trial of flexible- and fixed-dose regimens
&NA; Pregabalin binds with high affinity to the alpha2‐delta subunit protein of voltage‐gated calcium channels and, thereby, reduces release of excitatory neurotransmitters. This 12‐week randomised,… Expand
  • 527
  • 14
  • PDF
Ziconotide for treatment of severe chronic pain
Pharmacological management of severe chronic pain is difficult to achieve with currently available analgesic drugs, and remains a large unmet therapeutic need. The synthetic peptide ziconotide has… Expand
  • 236
  • 9
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Pregabalin for relief of neuropathic pain associated with diabetic neuropathy: A randomized, double‐blind study
Seven published, randomized, placebo‐controlled clinical trials with pregabalin have shown robust efficacy for relief of neuropathic pain from DPN and PHN. An investigation of the efficacy and safety… Expand
  • 197
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A cross-sectional cohort survey in 2100 patients with painful diabetic neuropathy and postherpetic neuralgia: Differences in demographic data and sensory symptoms
ABSTRACT Patients with neuropathic pain syndromes are heterogeneous. They present with a variety of sensory symptoms and pain qualities. The knowledge of these data and etiology‐specific differences… Expand
  • 256
  • 7
Pseudoradicular and radicular low-back pain – A disease continuum rather than different entities? Answers from quantitative sensory testing
&NA; To assess whether pseudoradicular low‐back pain may be associated with subclinical sensory deficits in the distal extremity, we applied the quantitative sensory testing protocol of the German… Expand
  • 140
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Screening of neuropathic pain components in patients with chronic back pain associated with nerve root compression: a prospective observational pilot study (MIPORT)
ABSTRACT Objective: Chronic back pain is characterized by a combination of neuropathic and nociceptive mechanisms of pain generation. The prevalence of the neuropathic pain component is unknown.… Expand
  • 126
  • 7
Peripheral neuropathic pain: a mechanism-related organizing principle based on sensory profiles
Abstract Patients with neuropathic pain are heterogeneous in etiology, pathophysiology, and clinical appearance. They exhibit a variety of pain-related sensory symptoms and signs (sensory profile).… Expand
  • 215
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  • PDF
The evaluation of neuropathic components in low back pain
Chronic low back pain is highly prevalent in Western societies. Large epidemiological studies show that 20% to 35% of patients with back pain suffer from a neuropathic pain component. Presently,… Expand
  • 182
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Opioids for chronic non-cancer pain
A 36 year old carpenter has a six month history of lower back pain with no specific clinical or radiological findings. As his pain has not responded to paracetamol and non-steroidal anti-inflammatory… Expand
  • 91
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