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A Drosophila model for fetal alcohol syndrome disorders: role for the insulin pathway
SUMMARY Prenatal exposure to ethanol in humans results in a wide range of developmental abnormalities, including growth deficiency, developmental delay, reduced brain size, permanent neurobehavioral… Expand
Spontaneous X chromosome MI and MII nondisjunction events in Drosophila melanogaster oocytes have different recombinational histories
Recent studies of human oocytes have demonstrated an enrichment for distal exchanges among meiosis I (MI) nondisjunction events and for proximal exchanges among meiosis II (MII) events. Our… Expand
The Drosophila female sterile mutation twin peaks is a novel allele of tramtrack and reveals a requirement for Ttk69 in epithelial morphogenesis.
The Drosophila gene tramtrack (ttk) encodes two transcriptional repressors, Ttk69 and Ttk88, which are required for normal embryogenesis and imaginal disc development. Here, we characterize a novel… Expand
Developmental Ethanol Exposure Leads to Dysregulation of Lipid Metabolism and Oxidative Stress in Drosophila
- Theresa Logan-Garbisch, Anthony Bortolazzo, +4 authors R. French
- Biology, Medicine
- G3: Genes, Genomes, Genetics
- 11 November 2014
Ethanol exposure during development causes an array of developmental abnormalities, both physiological and behavioral. In mammals, these abnormalities are collectively known as fetal alcohol effects… Expand
Glycogen synthase kinase-3/Shaggy mediates ethanol-induced excitotoxic cell death of Drosophila olfactory neurons
- R. French, U. Heberlein
- Medicine, Biology
- Proceedings of the National Academy of Sciences
- 8 December 2009
It has long been known that heavy alcohol consumption leads to neuropathology and neuronal death. While the response of neurons to an ethanol insult is strongly influenced by genetic background, the… Expand
Genetic aspects of behavioral neurotoxicology.
Considerable progress has been made over the past couple of decades concerning the molecular bases of neurobehavioral function and dysfunction. The field of neurobehavioral genetics is becoming… Expand
Division of labor: subsets of dorsal-appendage-forming cells control the shape of the entire tube.
- M. J. Boyle, R. French, K. A. Cosand, J. Dorman, D. P. Kiehart, C. Berg
- Biology, Medicine
- Developmental biology
- 1 October 2010
The function of an organ relies on its form, which in turn depends on the individual shapes of the cells that create it and the interactions between them. Despite remarkable progress in the field of… Expand
The genetic analysis of achiasmate segregation in Drosophila melanogaster. III. The wild-type product of the Axs gene is required for the meiotic segregation of achiasmate homologs.
The regular segregation of achiasmate chromosomes in Drosophila melanogaster females is ensured by two distinct segregational systems. The segregation of achiasmate homologs is assured by the… Expand
A Small Subset of Fruitless Subesophageal Neurons Modulate Early Courtship in Drosophila
We show that a small subset of two to six subesophageal neurons, expressing the male products of the male courtship master regulator gene products fruitlessMale (fruM), are required in the early… Expand