• Publications
  • Influence
The crystal structure of human deoxyhaemoglobin at 1.74 A resolution.
The structure of human deoxyhaemoglobin was refined at 1.74 A resolution using data collected on film at room temperature from a synchrotron X-ray source and the effects of intermolecular contacts on the structure were investigated.
Structure of the calcium-dependent lectin domain from a rat mannose-binding protein determined by MAD phasing.
The crystal structure of the carbohydrate-recognition domain of a rat mannose-binding protein, determined as the holmium-substituted complex by multiwavelength anomalous dispersion (MAD) phasing, reveals an unusual fold consisting of two distinct regions, one of which contains extensive nonregular secondary structure stabilized by two Holmium ions.
X-ray curved-crystal monochromator system at the storage ring DCI
Abstract Focusing in the horizontal plane is achieved by a Ge crystal shaped to an elongated triangle and mounted as a cantilever so that a cylindrical curvature is obtained with a single micrometer
Exploring hydrophobic sites in proteins with xenon or krypton
X‐ray diffraction is used to study the binding of xenon and krypton to a variety of crystallised proteins, and xenon complexes can be used to map hydrophobic sites in proteins, or as heavy‐atom derivatives in the isomorphous replacement method of structure determination.
High-pressure protein crystallography (HPPX): instrumentation, methodology and results on lysozyme crystals.
A new set-up and associated methodology for the collection of angle-dispersive diffraction data from protein crystals submitted to high hydrostastic pressure have been developed on beamline ID30 at
X‐ray structure of nucleoside diphosphate kinase.
The X‐ray structure of a point mutant of nucleoside diphosphate kinase (NDP kinase) from Dictyostelium discoideum has been determined to 2.2 A resolution and possible interactions of NDP kinase with other nucleotide binding proteins are discussed.
Bent crystal, bent multilayer optics on a multipole wiggler line for an x‐ray diffractometer with an imaging plate detector
A setup for diffraction and diffuse scattering studies on biological crystals, in the wavelength range 1.5–0.9 A, is operating on the superconducting wiggler line of the storage ring DCI at LURE.
High pressure macromolecular crystallography: the 140-MPa crystal structure at 2.3 A resolution of urate oxidase, a 135-kDa tetrameric assembly.
Results suggest that the onset of disruption of the tetrameric assembly by pressure has been captured in the crystalline state.
Toward fully fledged high-pressure macromolecular crystallography
Pressure allows one to explore the energy landscape and the various conformations of macromolecules. This might be one of the most interesting prospects of combining macromolecular crystallography
Crystal structure study of Opsanus tau parvalbumin by multiwavelength anomalous diffraction
The crystal structure of a small calcium‐binding protein, the parvalbumin IIIf from Opsanus tau in which Tb was substituted for Ca, has been analysed by multiwavelength anomalous diffraction and shows a good agreement with the model of the homologous carp parValbumin in regions of identical amino‐acid sequence.