• Publications
  • Influence
Stereoselective pharmacokinetics of ketoprofen in the rat. Influence of route of administration.
  • R. Foster, F. Jamali
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 1988
The 2-arylpropionic acid nonsteroidal anti-inflammatory drugs are usually administered as racemates. The enantiomers may have different pharmacokinetics and the R-isomer may metabolically invert toExpand
  • 61
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EXTRAHEPATIC FIRST‐PASS METABOLISM OF NIFEDIPINE IN THE RAT
The peroral (po) bioavailability of nifedipine is reported to range from about 45 to 58% in the rat; this compares favourably to human beings. The metabolism of nifedipine is similar in rats andExpand
  • 39
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PHARMACOKINETICS OF THE ENANTIOMERS OF VERAPAMIL AFTER INTRAVENOUS AND ORAL ADMINISTRATION OF RACEMIC VERAPAMIL IN A RAT MODEL
Verapamil is a chiral calcium channel blocking drug which is useful clinically as the racemate in treating hypertension and arrhythmia. The published pharmacokinetic data for verapamil enantiomers inExpand
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The Nifedipine Gastrointestinal Therapeutic System (GITS)
SummaryNifedipine is a short-acting calcium antagonist formulated into several different oral preparations, each of which offers a distinct drug release profile. Of these, the nifedipineExpand
  • 75
  • 2
ISATX247: a novel calcineurin inhibitor.
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Sensitive high-performance liquid chromatographic assay for nifedipine in human plasma utilizing ultraviolet detection.
A rapid, simple, sensitive and selective reversed-phase high-performance liquid chromatographic (HPLC) technique is reported for the determination of nifedipine in human plasma. The procedureExpand
  • 36
  • 1
Stereoselective metabolism of rac-mexiletine by the fungus Cunninghamella echinulata yields the major human metabolites hydroxymethylmexiletine and p-hydroxymexiletine.
rac-Mexiletine is an orally effective class 1b antiarrhythmic agent used to treat ventricular arrhythmias. In vivo experiments have demonstrated. It is predominantly metabolized by the liver with <Expand
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Stereospecific high-performance liquid chromatographic assay of acebutolol in human plasma and urine.
A sensitive high-performance liquid chromatographic technique is described for the separation of R- and S-acebutolol in human plasma and urine. The procedure involves derivatization with the chiralExpand
  • 10
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Protein binding of sotalol enantiomers in young and elderly human and rat serum using ultrafiltration
The protein binding of sotalol (STL) enantiomers was evaluated using an ultrafiltration technique with serum from young (32±2 years, n=5) and elderly (73±6 years, n=5) male and female humans, andExpand
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