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A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C
It is shown that a simple index using readily available laboratory results can identify CHC patients with significant fibrosis and cirrhosis with a high degree of accuracy and may decrease the need for staging liver biopsy specimens among patients with CHC. Expand
Results of a Prospective Study of Acute Liver Failure at 17 Tertiary Care Centers in the United States
- G. Ostapowicz, R. Fontana, +12 authors William M. Lee
- Annals of Internal Medicine
- 17 December 2002
The primary aim was to compare presenting clinical features and liver transplantation in patients with acute liver failure related to acetaminophen hepatotoxicity, other drugs, indeterminate factors, and other causes. Expand
Acetaminophen‐induced acute liver failure: Results of a United States multicenter, prospective study
In conclusion, acetaminophen hepatotoxicity far exceeds other causes of acute liver failure in the United States, and education of patients, physicians, and pharmacies to limit high‐risk use settings is recommended. Expand
ACG Clinical Guideline: The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury
- N. Chalasani, P. Hayashi, H. Bonkovsky, V. Navarro, William M. Lee, R. Fontana
- The American Journal of Gastroenterology
- 1 July 2014
This ACG Clinical Guideline is presented an evidence-based approach to diagnosis and management of DILI with special emphasis on DILi due to herbal and dietary supplements and DilI occurring in individuals with underlying liver disease. Expand
Ledipasvir and Sofosbuvir Plus Ribavirin for Treatment of HCV Infection in Patients With Advanced Liver Disease.
The combination of ledipasvir, sofosbuvir, and ribavirin for 12 weeks produced high rates of SVR12 in patients with advanced liver disease, including those with decompensated cirrhosis before and after liver transplantation. Expand
Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States.
This report summarizes the causes, clinical features, and outcomes from the first 300 patients enrolled in a prospective study to recruit patients with suspected idiosyncratic drug-induced liver injury and create a repository of biological samples for analysis. Expand
Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure.
Intravenous NAC improves transplant-free survival in patients with early stage non-acetaminophen-related acute liver failure and typically require emergency liver transplantation. Expand
Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study.
Mortality from DILI is significantly higher in individuals with pre-existing liver disease or concomitant severe skin reactions compared with patients without, and additional studies are needed to confirm the association between azithromycin and increased DILi in patients with chronic liver disease. Expand
Prognosis of hepatocellular carcinoma: Comparison of 7 staging systems in an American cohort
The Barcelona Clinic Liver Cancer (BCLC) staging system had the best independent predictive power for survival when compared with the other 6 prognostic systems and provided the best prognostic stratification for this cohort of patients with HCC. Expand
NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma in the United States.
- J. Marrero, R. Fontana, G. Su, H. Conjeevaram, Dawn M. Emick, A. Lok
- 1 December 2002
Hepatitis C and cryptogenic liver disease are the most common etiologies of diseases in patients with HCC, and NAFLD accounted for at least 13% of the cases. Expand