• Publications
  • Influence
A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing
MicroRNAs (miRNAs) are small noncoding regulatory RNAs that reduce stability and/or translation of fully or partially sequence-complementary target mRNAs. In order to identify miRNAs and to assessExpand
  • 3,259
  • 124
  • PDF
Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma.
BACKGROUND Lenalidomide is a structural analogue of thalidomide with similar but more potent biologic activity. This phase 3, placebo-controlled trial investigated the efficacy of lenalidomide plusExpand
  • 1,261
  • 60
  • PDF
Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study.
BACKGROUND Adults with relapsed or refractory B-precursor acute lymphoblastic leukaemia have an unfavourable prognosis. Blinatumomab is a bispecific T-cell engager antibody construct targeting CD19,Expand
  • 671
  • 52
Blinatumomab versus Chemotherapy for Advanced Acute Lymphoblastic Leukemia
Background Blinatumomab, a bispecific monoclonal antibody construct that enables CD3‐positive T cells to recognize and eliminate CD19‐positive acute lymphoblastic leukemia (ALL) blasts, was approvedExpand
  • 551
  • 43
  • PDF
Gene expression profile of adult T-cell acute lymphocytic leukemia identifies distinct subsets of patients with different response to therapy and survival.
Gene expression profiles were examined in 33 adult patients with T-cell acute lymphocytic leukemia (T-ALL). Nonspecific filtering criteria identified 313 genes differentially expressed in theExpand
  • 347
  • 37
  • PDF
Clinical utility of microarray-based gene expression profiling in the diagnosis and subclassification of leukemia: report from the International Microarray Innovations in Leukemia Study Group.
PURPOSE The Microarray Innovations in Leukemia study assessed the clinical utility of gene expression profiling as a single test to subtype leukemias into conventional categories of myeloid andExpand
  • 461
  • 32
  • PDF
Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation
Next generation sequencing and copy number analysis provide insights into the complexity of the CLL coding genome, and reveal an association between NOTCH1 mutational activation and poor prognosis.
  • 555
  • 30
  • PDF
Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin
Acute myeloid leukemia (AML) carrying NPM1 mutations and cytoplasmic nucleophosmin (NPMc+ AML) accounts for about one-third of adult AML and shows distinct features, including a unique geneExpand
  • 483
  • 28
Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia
The prognosis for adults with precursor B-cell acute lymphoblastic leukemia (B-ALL) remains poor, in part from a lack of therapeutic targets. We identified the type I cytokine receptor subunit CRLF2Expand
  • 269
  • 25
  • PDF
Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia.
MicroRNAs (miRNAs) are a novel class of small noncoding RNAs that modulate the expression of genes at the posttranscriptional level. These small molecules have been shown to be involved in cancer,Expand
  • 465
  • 24