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Chronic effects of agar, guar gum, gum arabic, locust-bean gum, or tara gum in F344 rats and B6C3F1 mice.
Under the conditions of these bioassays, none of the five polysaccharides was carcinogenic for F344 rats or B6C3F1 mice of either sex. Expand
Malaria (Plasmodium elongatum) in captive African penguins (Spheniscus demersus).
Ototoxicity of cis-dichlorodiammine platinum (II) in the guinea pig.
Ototoxic effects of cis-dichlorodiammine platinum (II) were evaluated by the disappearance of Preyer's reflex in response to pure tones of 5, 7, and 10 kHz and by histopathological evaluation of the inner ear with surface preparations or midmodiolar sections. Expand
Toxicity of camptothecin (NSC-100880).
Carcinogenesis bioassay of acetamide, hexanamide, adipamide, urea and P-tolylurea in mice and rats.
In male mice, acetamide, hexanamide, and p-tolylurea caused malignant lymphomas, and urea and adipamide were considered to be non-carcinogenic. Expand
Bleomycin-induced interstitial pneumonia in dogs
The intravenous administration of Bleomycin to 10 dogs at different dosages resulted in varying degrees of interstitial pneumonia in all cases and a lower incidence of nephrosis, foot pad excoriationExpand
Oral delta9-tetrahydrocannabinol toxicity in rats treated for periods up to six months.
The present investigation implicated reasonable doses of Δ 9 -THC in undesirable behavioral changes highlighted by fighting aggression, convulsive activity, and lethal cumulative toxicity in Fischer rats. Expand
cis-Dichlorodiammineplatinum(II) (NSC-119 875): preclinical toxicologic evaluation of intravenous injection in dogs, monkeys and mice.
Renal lesions were the most severe toxic changes in survivors and were manifested by azotemia, hypochloremia, proteinuria, appearance of urinary erythrocytes, leukocytes and decreased 24-hr excretion of lactate dehydrogenase in dogs and by protracted polyuria in monkeys. Expand
Scirrhous Eosinophilic Gastritis in Dogs with Gastric Arteritis
Three adult spayed female hunting dogs had an unusual form of chronic active gastritis that lasted for months to several years and its basis probably was immunologic. Expand
Toxicity of short-term administration of cannabinoids to rhesus monkeys.
The temporal pattern of adverse responses differentiated CBD, CBCH, and hashish oil and decreased testicular size and inhibition of spermatogenesis occurred. Expand