• Publications
  • Influence
Cold- and cryopreservation of dog liver and kidney slices.
The use of tissue slices in culture could decrease the number of animals used in health-related research and decrease experimental variation. This reduction may come about particularly if the methodsExpand
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Novel Nucleotide Human Immunodeficiency Virus Reverse Transcriptase Inhibitor GS-9148 with a Low Nephrotoxic Potential: Characterization of Renal Transport and Accumulation
ABSTRACT Accumulation of antiviral nucleotides in renal proximal tubules is controlled by their basolateral uptake via the human renal organic anion transporters type 1 (hOAT1) and 3 (hOAT3) andExpand
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Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II)
The effect of insulin-like growth factor II (IGF-II) on tumour development in the mouse mammary gland was studied. To promote extra IGF-II expression in the mammary gland, sheep beta-lactoglobulinExpand
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Cyclosporin A metabolism in human liver, kidney, and intestine slices. Comparison to rat and dog slices and human cell lines.
  • A. Vickers, V Fischer, +4 authors K. Brendel
  • Biology, Medicine
  • Drug metabolism and disposition: the biological…
  • 1 November 1992
This study assesses the contribution of cyclosporin A (CsA) metabolism at sites of CsA-induced toxicity: kidney and liver, and a site of absorption, the intestine. With organ slice cultures (8 mmExpand
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Disproportionate growth in mice with Igf-2 transgenes.
Injection transgenesis was used to study the long-term effects of excess insulin-like growth factor II on mouse growth and differentiation. By using a construct in which the coding region of theExpand
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Kidney Slices of Human and Rat to Characterize Cisplatin-Induced Injury on Cellular Pathways and Morphology
Kidney slices represent an in vitro model that has the cellular complexity of in vivo tissue to provide insights into mechanisms of organ injury, as shown in this study with the model nephrotoxicantExpand
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Adenosine A1 receptor promotion of multinucleated giant cell formation by human monocytes: a mechanism for methotrexate-induced nodulosis in rheumatoid arthritis.
OBJECTIVE To determine why methotrexate (MTX) exacerbates rheumatoid nodules in some patients, despite the effective suppression of synovial inflammation. METHODS Phorbol myristate acetateExpand
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The Use of Human Lung Slices in Toxicology
1 Successful use of agar-filled precision-cut rat lung slices in dynamic organ culture prompted the use of this technology with human lung. 2 The larger tissue mass of a human lung required that theExpand
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Cresol isomers: comparison of toxic potency in rat liver slices.
A comparison of the toxicity of cresol isomers (o-, m-, and p-methylphenol) was carried out using precision-cut rat liver slices as a test system. At equimolar concentrations p-cresol was the mostExpand
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Dynamic Organ Culture is Superior to Multiwell Plate Culture for Maintaining Precision-Cut Tissue Slices: Optimization of Tissue Slice Culture, Part 1
The increase in the use of precision-cut tissue slices for metabolism and toxicity studies has resulted in the development of various incubation systems and techniques for culturing the slices. ThisExpand
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