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Five Hundred Patients With Merkel Cell Carcinoma Evaluated at a Single Institution
TLDR
OS is a poor measure of the influence of MCC on life expectancy; the presence of lymphovascular invasion and clinically, but not microscopically, positive lymph nodes were associated with increased DSD, which should be incorporated into MCC staging and treatment recommendations. Expand
Murine dendritic cells pulsed with whole tumor lysates mediate potent antitumor immune responses in vitro and in vivo.
TLDR
In vitro and in vivo capacities of murine bone marrow-derived, cytokine-driven dendritic cells to elicit potent and specific anti-tumor responses when pulsed with whole tumor lysates are demonstrated. Expand
Melanoma, Version 2.2016, NCCN Clinical Practice Guidelines in Oncology.
This selection from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Melanoma focuses on adjuvant therapy and treatment of in-transit disease, because substantial changes wereExpand
Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label,
TLDR
This trial aimed to establish the safety, tolerability, and recommended phase 2 oral dose of the CCR2 inhibitor PF-04136309 in combination with FOLFIRINOX chemotherapy (oxaliplatin and irinotecan plus leucovorin and fluorouracil) and analysed the primary outcome by intention to treat. Expand
Driver Fusions and Their Implications in the Development and Treatment of Human Cancers
TLDR
Gene fusions represent an important class of somatic alterations in cancer, and integration of gene expression, copy number, and fusion annotation data revealed that fusions involving oncogenes tend to exhibit increased expression, whereas fusion involving tumor suppressors have the opposite effect. Expand
Regional Lymphadenectomy Is Indicated in the Surgical Treatment of Pancreatic Neuroendocrine Tumors (PNETs)
TLDR
Lymph node metastasis is predictive of poor outcomes in patients with pancreatic neuroendocrine tumors and preoperative variables are not able to reliably predict patients where the probability of lymph node involvement was less than 12%. Expand
Recurrence and Survival in Patients Undergoing Sentinel Lymph Node Biopsy for Merkel Cell Carcinoma: Analysis of 153 Patients from a Single Institution
TLDR
Patients with SLNB-positive disease are more likely to receive further treatment; however, sentinel lymph node (SLN) status is not associated with recurrence or survival; in contrast, LVI is strongly associated with both recurrence and survival. Expand
Rates and patterns of recurrence after curative intent resection for gastric cancer: a United States multi-institutional analysis.
TLDR
Recurrence was associated with worse survival, with a median recurrence-free survival of 10.8 months among those who experienced a recurrence, and nearly one-third of patients experienced recurrence after gastric cancer surgery. Expand
Survival Outcomes Associated With Clinical and Pathological Response Following Neoadjuvant FOLFIRINOX or Gemcitabine/Nab-Paclitaxel Chemotherapy in Resected Pancreatic Cancer.
TLDR
This large, multicenter study shows that improved biochemical, pathological, and clinical responses associated with NAC FLX or GNP result in improved OS, L-RFS, and MFS in PDAC. Expand
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