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Mechanisms of hair cell tuning.
Mechanosensory hair cells of the vertebrate inner ear contribute to acoustic tuning through feedback processes involving voltage-gated channels in the basolateral membrane and mechanotransduction…
The actions of calcium on the mechano‐electrical transducer current of turtle hair cells.
There was a concomitant irreversible loss of sensitivity to hair bundle displacements which the authors suggest is due to rupture of the mechanical linkages to the transducer channel, and the view that some consequences of reduced external Ca2+ stem from a decline in its intracellular concentration.
Activation and adaptation of transducer currents in turtle hair cells.
Transducer currents were recorded in turtle cochlear hair cells during mechanical stimulation of the hair bundle to suggest that adaptation may be partly controlled by influx of Ca2+ through the transducer channels.
Localization of inner hair cell mechanotransducer channels using high-speed calcium imaging
The observations, supported by theoretical simulations, suggest there are no functional mechanically sensitive transducer channels in first row stereocilia and imply the channels are present only at the bottom of the tip links.
The mechanical properties of ciliary bundles of turtle cochlear hair cells.
It is concluded that turtle cochlear hair cells contain an active force generating mechanism and is suggested that the hair bundle drives the fibre.
The sensory and motor roles of auditory hair cells
Recently identified proteins involved in the sensory and motor functions of auditory hair cells are described and evidence for each force generator is presented, likely to provide the high sensitivity and frequency discrimination of the mammalian cochlea.
Variation of membrane properties in hair cells isolated from the turtle cochlea.
The experimental aim was to relate the resonance properties seen during current injection to the membrane currents measured in the same cell under whole‐cell voltage clamp, supporting the contention that K+ is the major current carrier.
Prestin-Driven Cochlear Amplification Is Not Limited by the Outer Hair Cell Membrane Time Constant
Fast adaptation of mechanoelectrical transducer channels in mammalian cochlear hair cells
Measurements of mechanoelectrical transducer currents in outer hair cells of rats between postnatal days 5 and 18, before and after the onset of hearing suggest that sub-millisecond transducher adaptation can operate in outerhair cells under the ionic, driving force and temperature conditions that prevail in the intact mammalian cochlea.
Force generation by mammalian hair bundles supports a role in cochlear amplification
Hair bundles of mammalian outer hair cells can also produce force on a submillisecond timescale linked to adaptation of the mechanotransducer channels, which means that the bundle motor may ultimately be limited by the deactivation rate of the channels and could theoretically operate at high frequencies.