• Publications
  • Influence
Indolylarylsulfones carrying a heterocyclic tail as very potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors.
TLDR
The (R)-11 enantiomer proved to be exceptionally potent against the whole viral panel; in the reverse transcriptase (RT) screening assay, it was remarkably superior to NVP and EFV and comparable to ETV.
Synthesis and Cholinesterase Activity of Phenylcarbamates Related to Rivastigmine, a Therapeutic Agent for Alzheimer′s Disease.
TLDR
1-[1-(3-dimethylcarbamoyloxyphenyl)ethyl]piperidine (31b), in addition to a simple and cheaper synthesis, showed lower toxicity and very similar therapeutic index in comparison with Rivastigmine.
Synthesis and Evaluation as NOP Ligands of Some Spiro[piperidine‐4,2′(1′H)‐quinazolin]‐4′(3′H)‐ones and Spiro[piperidine‐4,5′(6′H)‐[1,2,4]triazolo[1,5‐c]quinazolines].
Some spiro[piperidine-4,2′(1′H)-quinazolin]-4′(3′H)-ones 3 and spiro[piperidine-4,5′(6′H)-[1,2,4]triazolo[1,5-c]quinazolines] 4 were synthesized and evaluated as ligands of the nociceptin receptor.
...
...