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A systematic review of the characteristics and validity of monitoring technologies to assess Parkinson’s disease
TLDR
A systematic review of technological-based devices used to measure motor function in individuals with Parkinson's disease and classified them into three groups, namely wearable, non-wearable and hybrid devices. Expand
Effectiveness of needle and syringe Programmes in people who inject drugs – An overview of systematic reviews
TLDR
It is found that NSP was effective in reducing HIV transmission and IRB among PWID, while there were mixed results regarding a reduction of HCV infection. Expand
CPAP and High-Flow Nasal Cannula Oxygen in Bronchiolitis.
TLDR
The pathophysiology of respiratory failure in bronchiolitis is reviewed, two randomized trials compared CPAP with oxygen delivered by low-flow nasal cannula or face mask and found some improvements in blood gas results and some physiologic parameters, but these trials were unable to demonstrate a reduction in the need for intubation. Expand
What guidance is available for researchers conducting overviews of reviews of healthcare interventions? A scoping review and qualitative metasummary
TLDR
This compilation of methodological guidance for conducting overviews of healthcare interventions will facilitate the production of future overviews and can help authors address key challenges they are likely to encounter. Expand
Quantifying Bias in Randomized Controlled Trials in Child Health: A Meta-Epidemiological Study
TLDR
Until further evidence is available, reviewers should not exclude RCTs from systematic reviews and meta-analyses based solely on risk of bias particularly in the area of child health, according to the Cochrane Database of Systematic Reviews. Expand
Glucocorticoids for acute viral bronchiolitis in infants and young children.
TLDR
Current evidence does not support a clinically relevant effect of systemic or inhaled glucocorticoids on admissions or length of hospitalisation, but combined dexamethasone and epinephrine may reduce outpatient admissions, but results are exploratory and safety data limited. Expand
Epinephrine for bronchiolitis.
TLDR
This review demonstrates the superiority of epinephrine compared to placebo for short-term outcomes for outpatients, particularly in the first 24 hours of care. Expand
Neutralizing Antibody and Botulinum Toxin Therapy: A Systematic Review and Meta-analysis
TLDR
NAbs was high among patients treated with RIMA but it was not associated with clinical non-responsiveness, and meta-analysis of the frequency of NAbs and SnR are limited by the heterogeneity of study design and reported outcomes. Expand
Evaluation of AMSTAR to assess the methodological quality of systematic reviews in overviews of reviews of healthcare interventions
TLDR
Results indicate that the AMSTAR tool can be used successfully in overviews that include Cochrane and non-Cochrane SRs, though decision rules may be useful to circumvent common challenges. Expand
Systematic reviews, overviews of reviews and comparative effectiveness reviews: a discussion of approaches to knowledge synthesis.
TLDR
Three approaches to synthesize evidence for healthcare interventions are discussed: systematic reviews (SRs), overviews of reviews and comparative effectiveness reviews. Expand
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