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Ion transport in sperm signaling.
TLDR
Combining in vivo measurements of membrane potential, intracellular ions, and second messengers with new molecular approaches and reconstitution strategies are revealing how sperm ion channels participate in motility, sperm maturation, and the acrosome reaction.
The mouse stargazer gene encodes a neuronal Ca2+-channel γ subunit
TLDR
The discovery that the stargazer gene encodes a γ subunit completes the identification of the major subunit types for neuronal Ca2+ channels, namely α1, α 2δ, β and γ, providing a new opportunity to understand how these channels function in the mammalian brain and how they may be targeted in the treatment of neuroexcitability disorders.
The mouse stargazer gene encodes a neuronal Ca2+-channel gamma subunit.
TLDR
The discovery that the stargazer gene encodes a gamma subunit completes the identification of the major subunit types for neuronal Ca2+ channels, namely alpha1, alpha2delta, beta and gamma, providing a new opportunity to understand how these channels function in the mammalian brain and how they may be targeted in the treatment of neuroexcitability disorders.
Expression and Subunit Interaction of Voltage-Dependent Ca2+ Channels in PC12 Cells
TLDR
Patch-clamp recordings show that in addition to the previously documented L-type and N-type Ca2+ currents, undifferentiated PC12 cells also express an ω-agatoxin-IVA-sensitive (P/Q-type) component and this is suggested to support a model for heterogenous β subunit association of the N- type Ca2-channel in a single cell type.
Dissection of Functional Domains of the Voltage-Dependent Ca2+ Channel α2δ Subunit
TLDR
The results indicate that the region of the α2δ subunit involved in the modulation of the gating properties of the high voltage-activated calcium channels is localized in the δ domain of the protein.
Inwardly rectifying K(+) channels in spermatogenic cells: functional expression and implication in sperm capacitation.
TLDR
Using patch-clamp recordings obtained from isolated mouse spermatogenic cells, the presence of a novel K(+)-selective inwardly rectifying current is documented, which may contribute to the cellular changes that give rise to the capacitated state in mature sperm.
Biochemical and Biophysical Evidence for γ2 Subunit Association with Neuronal Voltage-activated Ca2+Channels*
TLDR
The results suggest that the γ2 subunit is an important constituent of the neuronal Ca2+ channel complex and that it down-regulates neuronal Ca 2+ channel activity.
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