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The Viral and Cellular MicroRNA Targetome in Lymphoblastoid Cell Lines
TLDR
It is revealed that EBV miRNAs predominantly target cellular transcripts during latent infection, thereby manipulating the host environment, and myc-regulated host mi RNAs from the miR-17/92 cluster can regulate latent viral gene expression. Expand
Characterization and Intracellular Localization of the Epstein-Barr Virus Protein BFLF2: Interactions with BFRF1 and with the Nuclear Lamina
TLDR
The characterization of the product of the EBV BFLF2 gene is described, which belongs to a family of conserved herpesviral genes which include the UL31 genes of herpes simplex virus and of pseudorabies virus and whose products are known to interact with UL34, the positional homolog of BFRF1. Expand
An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function
TLDR
Two seemingly opposite cellular effects of TREM2 variants, namely reduced versus enhanced shedding, result in similar phenotypic outcomes by reducing cell surface TREM1 and lowering T REM2‐dependent phagocytosis. Expand
Spontaneous lytic replication and epitheliotropism define an Epstein-Barr virus strain found in carcinomas.
TLDR
It is reported that M81, a virus isolated from a Chinese patient with nasopharyngeal carcinoma (NPC), shows remarkable similarity to other NPC viruses but is divergent from all other known strains. Expand
Novel antibodies reveal presynaptic localization of C9orf72 protein and reduced protein levels in C9orf72 mutation carriers
TLDR
It is found that C9orf72 is a low abundant, cytoplasmic, highly soluble protein with the long 481 amino acid isoform being the predominant, if not exclusively, expressed protein isoform in mouse tissues and human brain. Expand
Interactions, localization, and phosphorylation of the m6A generating METTL3-METTL14-WTAP complex.
TLDR
It is confirmed that monomeric METTL3 is soluble and inactive while the catalytic center of METTL14 is degenerated and thus also inactive and it is shown that the C-terminal RGG repeats ofMETTL14 are required forMETTL3/14 activity by contributing to RNA substrate binding. Expand
Human natural killer cells prevent infectious mononucleosis features by targeting lytic Epstein-Barr virus infection.
TLDR
It is suggested that failure of innate immune control by human NK cells augments symptomatic lytic EBV infection, which drives lymphocyte expansion and predisposes for EBV-associated malignancies. Expand
BFRF1 of Epstein-Barr Virus Is Essential for Efficient Primary Viral Envelopment and Egress
TLDR
Electron microscopic observations showed that the reduction in viral titers was due to sequestration of EBV nucleocapsids in the nuclei of lytically induced cells, suggesting that BFRF1 is involved in transport of the maturing virion across the nuclear membrane. Expand
Cellular transcription factors recruit viral replication proteins to activate the Epstein–Barr virus origin of lytic DNA replication, oriLyt
TLDR
The data indicate that cellular transcriptional activators tether viral replication proteins to the lytic origin via direct protein–protein interactions to assemble the viral replication complex at oriLyt. Expand
The Epstein-Barr Virus-Encoded BILF1 Protein Modulates Immune Recognition of Endogenously Processed Antigen by Targeting Major Histocompatibility Complex Class I Molecules Trafficking on both the
TLDR
Initial observations on EBV-encoded BILF1 are extended to show that this immunoevasin can target MHC-I antigen presentation via both the exocytic and endocytic trafficking pathways. Expand
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