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Immunochemical characterization of Amaranthus retroflexus pollen extract: extensive cross-reactive allergenic components among the four species of Amaranthaceae/Chenopodiaceae.
TLDR
Three proteins with apparent MWs of 39, 45, and 66 kDa are suggested as the common allergenic components among the four pollens from the Amaranthaceae/Chenopodiaceae family. Expand
Potential therapeutic agents to COVID-19: An update review on antiviral therapy, immunotherapy, and cell therapy
TLDR
The present and potential future treatment strategies against COVID-19 are introduced and the advantages and disadvantages of each treatment strategy are defined. Expand
Exhaustion of T lymphocytes in the tumor microenvironment: Significance and effective mechanisms.
TLDR
The main components such as inhibitory receptors, inflammatory cells, stromal cells, cytokine milieu as well as environmental and metabolic conditions in TME which play role in development of exhaustion are discussed. Expand
Identification of methionine synthase (Sal k 3), as a novel allergen of Salsola kali pollen
TLDR
Sal k 3 represents a new allergen of S. kali pollen and seems to be an important allergenic compound in S.Kali allergic patients. Expand
Influence of processing on the allergenic properties of pistachio nut assessed in vitro.
TLDR
The most significant finding of the present study was the successful reduction of IgE-binding by pistachio extracts using steam-roast processing without any significant changes in sensory quality of product. Expand
Alpha‐lipoic acid and coenzyme Q10 combination ameliorates experimental diabetic neuropathy by modulating oxidative stress and apoptosis
TLDR
ALA and/or CoQ10 was proved to prevent apoptosis and degeneration of DRG neurons, which appears to be mediated by regulating the expression of caspase 3 and UCP2 proteins, inducing ATP and improving DN–induced changes inDRG neurons. Expand
A truncated Snail1 transcription factor alters expression of essential EMT markers and suppresses tumor cell migration in a human lung cancer cell line.
TLDR
Transfection of A549 cells with CSnail1 alters expression of essential EMT markers and consequently suppresses tumor cell migration, confirming capability of CSnails1 in EMT blocking and in parallel to current patents could be applied as a novel strategy in prevention of metastasis. Expand
Frequency of CD4+ and CD8+ T cells in Iranian chronic rhinosinusitis patients
TLDR
Evaluating the frequency of CD4+ and CD8+ T cells and macrophages in the sinonasal mucosa of CRS patients and investigating the specific transcription factors for Th1, Th2, Th17, and Treg cells demonstrated Th2 dominance in CRSwNP patients and Th17 dominance inCRSsNP patients, implicating different mechanisms underlie the disease. Expand
Challenges related to the immunogenicity of parenteral recombinant proteins: Underlying mechanisms and new approaches to overcome it
TLDR
This review article will focus on a number of factors, which play crucial roles in the human protein immunogenicity, and discusses available in silico, in vitro, and in vivo methods for the prediction of sequences, which may generate an immune response following parenteral administration of these proteins. Expand
Immunotherapy of Chenopodium album induced asthma by intranasal administration of CpG oligodeoxynucleotides in BALB/c mice.
TLDR
It is demonstrated that CpG ODN has therapeutic effects not only on splenocytes but also on nasal lymphocytes to produce IFN-gamma as a Th1 cytokine, and IL-10 as a regulatory cytokine. Expand
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