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The nuclear receptor superfamily: The second decade
This research presents a new probabilistic procedure called ‘spot-spot analysis’ to characterize the response of the immune system to the presence of E.coli. Expand
The RXR heterodimers and orphan receptors
The historical links between the steroid and nonsteroid receptor signaling systems are established, the explosive development of the retinoid X receptor (RXR) heterodimer and orphan receptor family is charted, the impact of these discoveries on the authors' understanding of the mechanisms of hormonal signaling is explained, and emerging issues and implications are presented. Expand
The steroid and thyroid hormone receptor superfamily.
- R. Evans
- Medicine, Biology
- 13 May 1988
A superfamily of regulatory proteins that include receptors for thyroid hormone and the vertebrate morphogen retinoic acid is identified, suggesting mechanisms underlying morphogenesis and homeostasis may be more ubiquitous than previously expected. Expand
SXR, a novel steroid and xenobiotic-sensing nuclear receptor.
A novel nuclear receptor is isolated, termed the steroid and xenobiotic receptor (SXR), which activates transcription in response to a diversity of natural and synthetic compounds, which suggests that broad specificity sensing receptors may represent a novel branch of the nuclear receptor superfamily. Expand
A transcriptional co-repressor that interacts with nuclear hormone receptors
A receptor-interacting factor, SMRT, is identified as a silencing mediator (co-repressor) for retinoid and thyroid-hormone receptors and a new class of cofactors which may be important mediators of hormone action are identified. Expand
Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ
The data suggest that the biologic effects of oxLDL are coordinated by two sets of receptors, one on the cell surface, which binds and internalizes the particle, and one in the nucleus, which is transcriptionally activated by its component lipids. Expand
Nuclear receptors and lipid physiology: opening the X-files.
Some general principles that govern the actions of this class of bioactive lipids and their nuclear receptors are considered here, and the scheme that emerges reveals a complex molecular script at work. Expand
Nuclear Receptor Coactivator ACTR Is a Novel Histone Acetyltransferase and Forms a Multimeric Activation Complex with P/CAF and CBP/p300
It is shown that purified ACTR is a potent histone acetyltransferase and appears to define a distinct evolutionary branch to this recently described family of coactivator complex. Expand
Regulation of Muscle Fiber Type and Running Endurance by PPARδ
The engineering of a mouse capable of continuous running of up to twice the distance of a wild-type littermate is described, achieved by targeted expression of an activated form of peroxisome proliferator-activated receptor δ (PPARδ) in skeletal muscle, which induces a switch to form increased numbers of type I muscle fibers. Expand
Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ
It is shown here that specific FAs, eicosanoids, and hypolipidemic drugs are ligands for PPARα or PPARδ, and a novel conformation-based assay is developed that screens activators for their ability to bind to PPAR α/δ and induce DNA binding. Expand