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Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex
It is indicated that cortical NMDARs are essential for the aggregation of layer IV cells into barrels and for development of the full complement of thalamocortical patterns.
Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval
Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice
Development and critical period plasticity of the barrel cortex
The development and patterning of the barrel cortex and the critical period plasticity are reviewed, allowing new insights into neural pattern formation in the neocortex and the mechanisms underlying critical period Plasticity.
NMDA Receptor-Dependent Pattern Transfer from Afferents to Postsynaptic Cells and Dendritic Differentiation in the Barrel Cortex
- Akash Datwani, T. Iwasato, S. Itohara, R. Erzurumlu
- BiologyMolecular and Cellular Neuroscience
- 1 November 2002
The results suggest that postsynaptic NMDAR activation is critical in communicating periphery-related sensory patterns from TCAs to barrel cells, and that layer IV spiny stellate cells remain imperceptive to patterning of their presynaptic inputs and elaborate exuberant dendritic specializations.
Neuropilin 1-Sema signaling regulates crossing of cingulate pioneering axons during development of the corpus callosum.
It is demonstrated that neuropilin 1 (Npn1) plays an integral role in the development of corpus callosum (CC) development, and axons from the cingulate cortex display guidance errors in Npn1(Sema-) mice, a knockin mouse line in which NPN1 is unable to bind Semas.
A Chemoattractant Role for NT-3 in Proprioceptive Axon Guidance
The results show that survival factor NT-3 acts as a short-distance axon guidance molecule for muscle sensory afferents as they approach their proper targets.
Mapping the face in the somatosensory brainstem
This work has revealed that early molecular regionalization and positional patterning of trigeminal ganglion and brainstem target neurons are established by homeodomain transcription factors, the expression of which is induced and maintained by signals from the brain and face.
A comparison of pattern formation by thalamocortical and serotonergic afferents in the rat barrel field cortex.
It is concluded that p-chloroamphetamine (PCA) treatment does not prevent formation of a vibrissa-specific pattern by thalamocortical afferents, and the possibility that the 5-HT axons may play a trophic role in the maturation of VB Afferents is discussed.
Trigeminal ganglion cell processes are spatially ordered prior to the differentiation of the vibrissa pad
The results show that trigeminal ganglion cell processes are spatially ordered as they reach their peripheral and central targets on embryonic day 12 (E12), which precedes the emergence of vibrissa rows in the periphery and the differentiation of brainstem trigeminals nuclei.