• Publications
  • Influence
Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex
In the rodent primary somatosensory cortex, the configuration of whiskers and sinus hairs on the snout and of receptor-dense zones on the paws is topographically represented as discrete modules ofExpand
  • 458
  • 46
  • PDF
Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice
Sensory pathways of the brain generally develop from crudely wired networks to precisely organized systems. Several studies have implicated neural activity-dependent mechanisms, includingExpand
  • 452
  • 19
Development and critical period plasticity of the barrel cortex
In primary sensory neocortical areas of mammals, the distribution of sensory receptors is mapped with topographic precision and amplification in proportion to the peripheral receptor density. TheExpand
  • 211
  • 14
NMDA Receptor-Dependent Pattern Transfer from Afferents to Postsynaptic Cells and Dendritic Differentiation in the Barrel Cortex
N-Methyl-D-aspartate receptors (NMDARs) are important for synaptic refinement during development. In CxNR1KO mice, cortical excitatory neurons lack NR1, the essential subunit of the NMDAR, and inExpand
  • 102
  • 12
  • PDF
Neuropilin 1-Sema signaling regulates crossing of cingulate pioneering axons during development of the corpus callosum.
Pioneer axons from the cingulate cortex initiate corpus callosum (CC) development, yet nothing is known about the molecules that regulate their guidance. We demonstrate that neuropilin 1 (Npn1) playsExpand
  • 101
  • 9
  • PDF
A Chemoattractant Role for NT-3 in Proprioceptive Axon Guidance
Neurotrophin-3 (NT-3) is required for proprioceptive neuron survival. Deletion of the proapoptotic gene Bax in NT-3 knockout mice rescues these neurons and allows for examination of their axon growthExpand
  • 50
  • 9
Slit2, a Branching–Arborization Factor for Sensory Axons in the Mammalian CNS
Axons that carry information from the sensory periphery first elongate unbranched and form precisely ordered tracts within the CNS. Later, they begin collateralizing into their proper targets andExpand
  • 82
  • 8
  • PDF
Trigeminal ganglion cell processes are spatially ordered prior to the differentiation of the vibrissa pad
The rodent trigeminal system is characterized by the punctate organization of its afferents and neurons that replicate the distribution of mystacial vibrissae and sinus hairs on the snout. We haveExpand
  • 88
  • 7
  • PDF
A comparison of pattern formation by thalamocortical and serotonergic afferents in the rat barrel field cortex.
In the present study we compare the formation of vibrissa-related patterns by thalamocortical afferents from the ventrobasal (VB) nucleus to that by raphe-cortical, serotonergic afferents from theExpand
  • 132
  • 6