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Genetic studies of body mass index yield new insights for obesity biology
A genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals provide strong support for a role of the central nervous system in obesity susceptibility.
Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy.
- C. Templin, J. Ghadri, T. Lüscher
- Medicine, PsychologyThe New England journal of medicine
- 2 September 2015
Patients with takotsubo cardiomyopathy had a higher prevalence of neurologic or psychiatric disorders than did those with an acute coronary syndrome and physical triggers, acute neurologics or psychiatric diseases, high troponin levels, and a low ejection fraction on admission were independent predictors for in-hospital complications.
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
A meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, finds a long tail of additional common variant loci explaining much of the variation in susceptibility to type 2 diabetes.
ESC Guidelines on the Diagnosis and Treatment of Peripheral Artery Diseases
Defining the role of common variation in the genomic and biological architecture of adult human height
The results indicate a genetic architecture for human height that is characterized by a very large but finite number of causal variants, including mTOR, osteoglycin and binding of hyaluronic acid.
Association of a human G-protein β3 subunit variant with hypertension
A novel polymorphism (C825T) in exon 10 of the gene encoding the p3 subunit of heterotrimeric G proteins (GNB3) is detected, which suggests a significant association of the T allele with essential hypertension.
New genetic loci link adipose and insulin biology to body fat distribution
A genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial.
Guidelines on the diagnosis and management of pericardial diseases executive summary; The Task force on the diagnosis and management of pericardial diseases of the European society of cardiology.
Update on myocardial bridging.
Clinical relevant aspects of myocardial bridging are summarized with an emphasis on morphological and hemodynamic alterations and their representation in imaging techniques, which is crucial for establishing a link between systolic compression and the clinical presentation, and hence for commencing appropriate therapy.