R. Epand

Publications618
h-index75
Citations23,170
Highly Influential Citations551
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Diversity of antimicrobial peptides and their mechanisms of action.
  • R. Epand, H. Vogel
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 15 December 1999
Antimicrobial peptides encompass a wide variety of structural motifs. Many peptides have alpha-helical structures. The majority of these peptides are cationic and amphipathic but there are also… Expand
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Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity.
Huntington's disease is caused by an expanded polyglutamine tract in huntingtin protein, leading to accumulation of huntingtin in the nuclei of striatal neurons. The 18 amino-acid amino-terminus of… Expand
  • 316
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Tocopherols and tocotrienols in membranes: a critical review.
The familiar role of tocols (tocopherols and tocotrienols) as lipid-soluble chain-terminating inhibitors of lipid peroxidation is currently in the midst of a reinterpretation. New biological… Expand
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Regulation and functions of diacylglycerol kinases.
4.1. Regulation of Immune Function 6194 4.2. Cell Proliferation and Cancer 6195 4.3. Brain Function 6196 4.4. Cardiac Function 6197 4.5. Glucose Homeostasis 6197 4.6. Vision 6198 5.… Expand
  • 144
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Interaction with a Membrane Surface Triggers a Reversible Conformational Change in Bax Normally Associated with Induction of Apoptosis*
The Bcl-2 family member Bax is an apoptosis-promoting protein that normally resides in an inactive state within the cytoplasm of healthy cells. Upon induction of apoptosis by diverse stimuli, Bax… Expand
  • 201
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Relationship of membrane curvature to the formation of pores by magainin 2.
Magainin 2, an antimicrobial peptide from the Xenopus skin, kills bacteria by permeabilizing the cell membranes. We have proposed that the peptide preferentially interacts with acidic phospholipids… Expand
  • 401
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The Phosphocreatine Circuit: Molecular and Cellular Physiology of Creatine Kinases, Sensitivity to Free Radicals, and Enhancement by Creatine Supplementation
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High-quality 3D structures shine light on antibacterial, anti-biofilm and antiviral activities of human cathelicidin LL-37 and its fragments.
Host defense antimicrobial peptides are key components of human innate immunity that plays an indispensible role in human health. While there are multiple copies of cathelicidin genes in horses,… Expand
  • 112
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NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy
Mitophagy is critical for cell homeostasis. Externalization of the inner mitochondrial membrane phospholipid, cardiolipin (CL), to the surface of the outer mitochondrial membrane (OMM) was identified… Expand
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The mechanism of lamellar-to-inverted hexagonal phase transitions in phosphatidylethanolamine: implications for membrane fusion mechanisms.
We studied the mechanism of the lamellar-to-inverted hexagonal (L alpha/H[II]) phase transition, using time-resolved cryotransmission electron microscopy (TRC-TEM), 31P-NMR, and differential scanning… Expand
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