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Tocopherols and tocotrienols in membranes: a critical review.
This review will outline what is known about the location and behaviour of tocols in phospholipid bilayers to assist researchers when designing new experiments and when critically assessing the results, in turn providing a more thorough understanding of the biochemistry of to cols. Expand
Interaction with a Membrane Surface Triggers a Reversible Conformational Change in Bax Normally Associated with Induction of Apoptosis*
- J. Yethon, R. Epand, B. Leber, R. Epand, D. Andrews
- Chemistry, Medicine
- Journal of Biological Chemistry
- 5 December 2003
It is reported that purified Bax undergoes a reversible conformational change upon incubation with lipid vesicles in the absence of other proteins, providing evidence that Bax activation proceeds in a stepwise fashion, with multiple triggers and potential levels of regulation. Expand
High-quality 3D structures shine light on antibacterial, anti-biofilm and antiviral activities of human cathelicidin LL-37 and its fragments.
- G. Wang, Biswajit Mishra, R. Epand, R. Epand
- Biology, Medicine
- Biochimica et biophysica acta
- 1 September 2014
This article reviews recent advances made in structural and biophysical studies of human LL-37 and its fragments, which serve as a basis to understand their antibacterial, anti-biofilm and antiviral activities and mapping the functional roles of the cationic amino acids of the major antimicrobial region ofLL-37 provides a basis for designing antimicrobial peptides with desired properties. Expand
Rigid amphipathic fusion inhibitors, small molecule antiviral compounds against enveloped viruses
- M. St-Vincent, Che C. Colpitts, +10 authors L. Schang
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 7 September 2010
A family of synthetic rigid amphiphiles of shape similar to such phospholipids, RAFIs (rigid amphipathic fusion inhibitors), inhibit the infectivity of several otherwise unrelated enveloped viruses, including hepatitis C and HSV-1 and -2, with no cytotoxic or cytostatic effects. Expand
Inhibition of HIV-1 endocytosis allows lipid mixing at the plasma membrane, but not complete fusion
The block of HIV-1 fusion with the plasma membrane at a post-lipid mixing stage shows that this membrane is not conducive to fusion pore formation and/or enlargement, and the ability of dynasore to interfere with the virus-endosome fusion suggests that dynamin could be involved in two distinct steps of HIV - endocytosis and fusion within intracellular compartments. Expand
Bacterial lipid composition and the antimicrobial efficacy of cationic steroid compounds (Ceragenins).
The antimicrobial action of the ceragenins correlates better with the content of phosphatidylethanolamine in the bacterial membrane than whether or not the bacteria has an outer membrane, suggesting that the bacterial lipid composition can be an important factor in determining the sensitivity of bacteria to antimicrobial agents. Expand
Effects of increasing hydrophobicity on the physical-chemical and biological properties of a class A amphipathic helical peptide.
- G. Datta, M. Chaddha, +10 authors G. Anantharamaiah
- Chemistry, Medicine
- Journal of lipid research
- 1 July 2001
The effects of increasing the hydrophobicity of a series of homologous class A amphipathic peptides, including 5F, on physical and functional properties related to atherosclerosis inhibition by systematically replacing existing nonpolar amino acids with phenylalanine suggest that an appropriate balance between peptide-peptide and peptides-lipid interactions is required for optimal biological activity of amphipaths. Expand
Caveolin scaffolding region and cholesterol-rich domains in membranes.
It is concluded that the peptides the authors studied containing CRAC sequences are more effective in promoting the formation of cholesterol-rich domains than are shorter peptides of this region of caveolin, which although they contain several aromatic amino acids, they have no CRAC motif. Expand
A Novel Linear Amphipathic β-Sheet Cationic Antimicrobial Peptide with Enhanced Selectivity for Bacterial Lipids*
- J. Blazyk, R. Wiegand, +5 authors U. Kari
- Chemistry, Biology
- The Journal of Biological Chemistry
- 14 May 2001
An 18-residue peptide is designed, (KIGAKI)3-NH2, that has no amphipathic character as an α-helix but can form a highly amphipATHic β-sheet when bound to lipids and which was much less effective at inducing leakage in lipid vesicles composed of mixtures of the acidic lipid and neutral lipid. Expand