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Inhibition of Succinate Dehydrogenase by Malonic Acid Produces an “Excitotoxic” Lesion in Rat Striatum
Abstract: Excitotoxicity and defects in neuronal energy metabolism have both been implicated in the pathogenesis of neurode‐generative disease. These two mechanisms may be linked through the NMDAExpand
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Antiparkinsonian effects of remacemide hydrochloride, a glutamate antagonist, in rodent and primate models of Parkinson's disease
Loss of dopaminergic innervation of the striatum results in overactivity of the glutamatergic pathways from the subthalamic nucleus to the internal segment of the globus pallidus and the substantiaExpand
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Quantitative Autoradiography of Dihydrorotenone Binding to Complex I of the Electron Transport Chain
Abstract: Defective complex I activity has been linked to Parkinson's disease and Huntington's disease, but little is known of the regional distribution of this enzyme in the brain. We have developedExpand
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NMDA and AMPA Receptors in Transgenic Mice Expressing Human β‐Amyloid Protein
The human β‐amyloid protein may play an important, possibly primary, role in the pathogenesis of Alzheimer's disease (AD), and it appears to potentiate the susceptibility of neurons toExpand
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NMDA and AMPA receptors in transgenic mice expressing human beta-amyloid protein.
The human beta-amyloid protein may play an important, possibly primary, role in the pathogenesis of Alzheimer's disease (AD), and it appears to potentiate the susceptibility of neurons toExpand
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PLASTIC MATERIALS FOR LATE 80'S INSTRUMENT PANEL DESIGN
The paper identifies how the changes in automotive design criteria, specifications, manufacturing methods and occupant safety considerations are likely to affect resin selection and fabrication forExpand