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Liposome-encapsulated doxorubicin targeted to CD44: a strategy to kill CD44-overexpressing tumor cells.
Certain tumors, including many that are found in the lung, overexpress the CD44 cell-surface marker. CD44 is a receptor that binds to hyaluronan (HA), a carbohydrate consisting of beta1,3 N-acetyl… Expand
Determination and Modeling of Kinetics of Cancer Cell Killing by Doxorubicin and Doxorubicin Encapsulated in Targeted Liposomes
Various mathematical approaches have been devised to relate the cytotoxic effect of drugs in cell culture to the drug concentration added to the cell culture medium. Such approaches can… Expand
Characterization of a polymeric PLGA-injectable implant delivery system for the controlled release of proteins.
Physico-chemical properties of injectable polymeric implant systems, based on the principle that a water-insoluble polymer dissolved in a biocompatible solvent will precipitate upon contact with… Expand
Delivery of Soluble Tumor Necrosis Factor Receptor from In-Situ Forming PLGA Implants: In-Vivo
Many harmful effects of tumor necrosis factor (TNF) result from chronic formation of this cytokine at certain distinct loci in the body. The soluble forms of the TNF receptors p55 and p75, which have… Expand
Dopamine D2 receptor gene variants and response to rasagiline in early Parkinson's disease: a pharmacogenetic study.
The treatment of early Parkinson's disease with dopaminergic agents remains the mainstay of symptomatic therapy for this incurable neurodegenerative disorder. However, clinical responses to… Expand
Interactions of hyaluronan-targeted liposomes with cultured cells: modeling of binding and endocytosis.
Placebo-controlled evaluation of a bioengineered, cocaine-metabolizing fusion protein, TV-1380 (AlbuBChE), in the treatment of cocaine dependence.
- Y. Gilgun-Sherki, R. Eliaz, +7 authors S. Gyaw
- Psychology, Medicine
- Drug and alcohol dependence
- 1 September 2016
BACKGROUND TV-1380 (AlbuChE) is a novel recombinant fusion protein of mutated butyrylcholinesterase (BChE) that has increased catalytic efficiency for cocaine metabolism compared to wild-type BChE.… Expand
Efficacy of rasagiline in early Parkinson's disease: a meta-analysis of data from the TEMPO and ADAGIO studies
- R. Hauser, V. Abler, E. Eyal, R. Eliaz
- Psychology, Medicine
- The International journal of neuroscience
- 18 March 2016
Aim of the study: To evaluate the efficacy of rasagiline versus placebo in a pooled population of patients with early Parkinson's disease (PD). Materials and methods: TEMPO and ADAGIO were Phase III… Expand
Long-term protection against the effects of tumour necrosis factor by controlled delivery of the soluble p55 TNF receptor.
Chronic inflammatory diseases are associated with increased soluble tumour necrosis factor (TNF) receptor concentrations in serum. To obtain such an increase, we implanted mice with ethylene… Expand
Robust and prolonged gene expression from injectable polymeric implants
We introduce an injectable system for the formation of a biodegradable DNA-containing implant that releases DNA over a 2-month period to provide a robust and prolonged gene expression at the site.… Expand