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Industrial production of β-lactam antibiotics
- R. Elander
- Applied Microbiology and Biotechnology
- 3 April 2003
The industrial production of β-lactam antibiotics by fermentation over the past 50 years is one of the outstanding examples of biotechnology. Today, the β-lactam antibiotics, particularly penicillins… Expand
Industrial production of beta-lactam antibiotics.
- R. Elander
- Applied microbiology and biotechnology
The industrial production of beta-lactam antibiotics by fermentation over the past 50 years is one of the outstanding examples of biotechnology. Today, the beta-lactam antibiotics, particularly… Expand
The β-lactam antibiotics: past, present, and future
The discovery and development of the β-lactam antibiotics are among the most powerful and successful achievements of modern science and technology. Since Fleming's accidental discovery of the… Expand
Metabolism of tryptophan by Pseudomonas aureofaciens. 3. Production of substituted pyrrolnitrins from tryptophan analogues.
Exogenous tryptophan is metabolized by Pseudomonas aureofaciens to yield pyrrolnitrin [3-chloro-4-(2'-nitro-3'-chlorophenyl)-pyrrole], an antifungal agent. The ability of this culture to metabolize… Expand
Preparation of substituted phenyl pyrroles through the metabolism of tryptophan analogues.
Metabolism of tryptophans by Pseudomonas aureofaciens. VI. Production of pyrrolnitrin by selected Pseudomonas species.
Twenty-nine strains of Pseudomonas, classified as P. fluorescens biotype D or E or as P. multivorans, were examined for the production of pyrrolnitrin, an antifungal agent synthesized in P.… Expand
Polymerase chain reaction in mycology: an overview.
Penicillin production by glucose-derepressed mutants ofPenicillium chrysogenum
- L. T. Chang, E. McGrory, R. Elander
- Biology, Medicine
- Journal of Industrial Microbiology
- 1 November 1990
SummaryWild-type strains ofPenicillium chrysogenum produce lower penicillin V titers in media containing excess glucose. Two mutant strains were isolated and shown to produce normal penicillin V… Expand
Strain Improvement and Preservation of β -Lactam-Producing Microorganisms
- R. Elander
The initial discovery of Fleming’s contaminating Penicillium fungus and its remarkable antibacterial properties now date back more than 50 years. Although the Oxford group proposed in 1943 that… Expand