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Nonenzymatic Glucosylation of Low-Density Lipoprotein Alters Its Biologic Activity
TLDR
Since, like other plasma proteins, LDL undergoes glucosylation in diabetes, its turnover and sites of catabolism may differ from normal and this may be relevant to the accelerated atherosclerosis of diabetes. Expand
Cholestyramine-induced changes in low density lipoprotein composition and metabolism. I. Studies in the guinea pig.
TLDR
The studies show that the effects of bile sequestration are complex and that the compositional changes produced have profound metabolic consequences and the implications for interpretation of LDL turnover studies are discussed. Expand
Altered apolipoprotein B metabolism in very low density lipoprotein from lovastatin-treated guinea pigs.
TLDR
Data indicate that L-VLDL was irreversibly removed from the plasma of an untreated guinea pig more rapidly than was C-V LDL, indicating that the metabolic behavior of VLDL apoB is affected by lovastatin. Expand
Comparison of glucosylated low density lipoprotein with methylated or cyclohexanedione-treated low density lipoprotein in the measurement of receptor-independent low density lipoprotein catabolism.
TLDR
Glucosylation of LDL did not affect receptor-independent degradation in vivo, as the turnover of GLC-LDL and native LDL were similar in the LDL receptor-deficient, Watanabe heritable hyperlipidemic rabbit. Expand
Turnover and tissue sites of degradation of glucosylated low density lipoprotein in normal and immunized rabbits.
TLDR
The presence of humoral antibodies to modified LDL acts to rapidly remove such LDL from plasma and specifically targets such complexes to reticuloendothelial cells, primarily in the liver, in this manner such antibodies may serve a useful purpose. Expand
Nonenzymatic Glucosylation of High-Density Lipoprotein Accelerates Its Catabolism in Guinea pigs
TLDR
With increasing amounts of glucose incorporated there was a proportionate increase in the rate of clearance of glcHDL when injected intravenously into guinea pigs, which may be relevant to the decreased HDL levels observed in diabetic subjects. Expand
Effects of lovastatin therapy on guinea pig low density lipoprotein composition and metabolism.
TLDR
When a single LDL tracer was injected into control and lovastatin-treated guinea pigs, the FCR was always more rapid in the lovastarin-treated animals, and when one compared the F CR of the C-LDL determined in control animals with the FSR of the L- LDL there was no difference, possible explanations for these paradoxical findings are discussed. Expand
Direct gene transfer to the liver with herpes simplex virus type 1 vectors: transient production of physiologically relevant levels of circulating factor IX.
TLDR
Although the level of transgene expression from the hCMV promoter was transient, a significant number of persistent vectors could be rescued from the livers of recipient mice up to 2 months after inoculation, suggesting that clinically useful gene transfer may eventually be feasible through direct vector delivery to the liver. Expand
Post-transcriptional regulation of retroviral vector-transduced low density lipoprotein receptor activity.
TLDR
St sterol-mediated down-regulation of receptor protein in the infected cells is demonstrated by a mechanism that appears to be mediated at a post-transcriptional level, suggesting the existence of post- transcriptionallevel mechanisms that are responsible for sterol regulation of expression of the transduced LDL receptor gene. Expand
Long-term transgene expression from genetically modified hepatocytes grafted to the rat liver.
Primary cultures of rat hepatocytes embedded and grown to high density in a wafer of reticulated polyurethane have been infected in vitro with a retroviral vector expressing the hepatitis B virusExpand
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