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Vasoactive peptide release in the extracerebral circulation of humans during migraine headache
TLDR
A substantial elevation of the calcitonin gene‐related peptide level in the external jugular but not the cubital fossa blood was seen in both classic and common migraine, and may have importance in the pathophysiology of migraine.
Sample purification and preparation technique based on nano-scale reversed-phase columns for the sensitive analysis of complex peptide mixtures by matrix-assisted laser desorption/ionization mass
TLDR
It is shown that 2,5-dihydroxybenzoic acid (DHB) acts as an efficient matrix for peptide mapping and both detection sensitivity and sequence coverage are comparable to those obtained with the currently preferred matrix alpha-cyano-4-hydroxycinnamic acid (CHCA).
Discovery of endogenous catecholamines in lymphocytes and evidence for catecholamine regulation of lymphocyte function via an autocrine loop.
TLDR
Results suggest the presence of an autocrine loop whereby lymphocytes down-regulate their own activity, and intracellular dopamine levels are shown to be increased by extra-cellular dopamine, suggesting a cellular-uptake mechanism.
Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system
TLDR
The observation of elevation of substance P—like and CGRP‐like immunoreactivity after activation of the nociceptive afferent system of the head provides new insights into a putative role of peptides in the pathophysiology of migraine and cluster headache, and suggests new areas of possible therapeutic intervention.
Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: preliminary evidence for association with preproNPY gene polymorphism.
TLDR
Levels of NPY-like immunoreactivity (NPY-LI) in the cerebrospinal fluid of medication-free subjects with treatment refractory unipolar depression are examined, supporting the notion that impaired NPY function could contribute to depressive illness.
Corticotropin-releasing factor and neuropeptide y: role in emotional integration
TLDR
The amygdala complex integrates stressful stimuli and is critical in transducing their aversive value into autonomic, endocrine and behavioural responses, and recent evidence suggests that two neuropeptides exert a reciprocal regulation of responsiveness to stressful stimuli.
Catecholamines are synthesized by mouse lymphocytes and regulate function of these cells by induction of apoptosis
TLDR
It is demonstrated that catecholamines are actively produced by lymphocytes and have the capacity to act as auto‐ and/or paracrine regulators of lymphocyte activity through induction of apoptosis.
Suppressed neuropeptide Y (NPY) mRNA in rat amygdala following restraint stress
TLDR
The present findings support the hypothesis that anxiety related behavioral effects of stress may in part be mediated through modulation of NPY function in the amygdala.
Calcitonin Gene-Related Peptide and Cerebral Blood Vessels: Distribution and Vasomotor Effects
TLDR
Cardiovascular nerve fibers containing CGRP appear to be present in all mammalian species (although to varying degrees) and C GRP is invariably a potent dilator of the cerebral arteries for all species.
Neuropeptide Y and peptide YY as possible cerebrospinal fluid markers for major depression and schizophrenia, respectively.
TLDR
The finding of reduced CSF concentrations of NPY in patients with major depression and of reduced PYY concentrations in schizophrenia may reflect disturbed synthesis, turnover or degradation of the peptides.
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