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A simple and sensitive saturation assay method for the measurement of adenosine 3':5'-cyclic monophosphate.
Guidelines for immunoassay data processing.
These guidelines outline the minimum requirements for a data-processing package to be used in the immunoassay laboratory and outline the statistical analyses that should be performed to obtain the analyte concentrations of unknown specimens and to ensure adequate monitoring of within- and between-assay errors of measurement.
A sensitive, precise radioimmunoassay of serum insulin relying on charcoal separation of bound and free hormone moieties.
- R. Ekins
- BiologyJournal of pharmaceutical and biomedical analysis
Measurement of free hormones in blood.
- R. Ekins
- BiologyEndocrine reviews
- 1 February 1990
It is suggested that it is plausible, purely on physicochemical grounds, that the characteristic changes in binding protein levels seen in pregnancy serve to redistribute hormone throughout the body, specifically (in the case of the thyroid hormones) directing T4 to the feto-placental unit.
Pregnancy-induced changes in thyroid function: role of human chorionic gonadotropin as putative regulator of maternal thyroid.
- M. Ballabio, M. Poshychinda, R. Ekins
- Medicine, BiologyThe Journal of clinical endocrinology and…
- 1 October 1991
The differing patterns of circulating hCG at various stages of gestation suggest that distinct hCG isoforms may regulate maternal thyroid activity.
The free hormone hypothesis and measurement of free hormones.
- R. Ekins
- MedicineClinical chemistry
- 1 July 1992
A strategy for thyroid function tests.
The clinical uncertainty in distinguishing borderline cases of hyperthyroidism and hypothyroidism among 1559 consecutive requests for thyroid function tests was 47% reduced by using the free thyroxine index and to under 2% by using specific tests determined by the decision-aiding ranges.
On the meaning of "sensitivity".
Arguments against retention of the "slope" definition are advanced, which conflicts with the word's common meaning and is meaningless as an indicator of the performance of a measuring system.
Maternal hypothyroxinemia disrupts neurotransmitter metabolic enzymes in developing brain.
- I. Evans, A. Sinha, M. Pickard, P. R. Edwards, A. Leonard, R. Ekins
- Biology, MedicineThe Journal of endocrinology
- 1 May 1999
The prenatal disturbances noted in this study may have wide-ranging consequences since they occur when neurotransmitters have putative neurotropic roles in brain development and may affect neurotransmission, thereby contributing to the behavioural dysfunction seen in adult progeny of hypothyroxinemic dams.