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Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor.
A human member of the immunoglobulin superfamily was shown to mediate entry of several alphaherpesviruses, including herpes simplex viruses (HSV) 1 and 2, porcine pseudorabies virus (PRV), and bovine…
LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator.
Crystal Structure of Glycoprotein B from Herpes Simplex Virus 1
The crystal structure of the gB ectodomain from herpes simplex virus type 1 reveals a multidomain trimer with unexpected homology to glycoprotein G from vesicular stomatitis virus (VSV G).
A Novel Role for 3-O-Sulfated Heparan Sulfate in Herpes Simplex Virus 1 Entry
Crystal structure of the conserved herpesvirus fusion regulator complex gH–gL
- T. K. Chowdary, Tina M. Cairns, D. Atanasiu, G. Cohen, R. Eisenberg, E. Heldwein
- BiologyNature Structural &Molecular Biology
- 1 July 2010
The crystal structure of the gH ectodomain bound to gL from herpes simplex virus 2 is determined and it is proposed that gH– gL activates gB for fusion, possibly through direct binding, making the gB–gH–gL interface a promising antiviral target.
A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus.
Differences in ability of HSV-1 andHSV-2 strains to use HveB for entry should influence the types of cells that can be infected and thereby account in part for serotype and strain differences in tissue tropism and pathogenicity.
Protective Immunity to Vaccinia Virus Induced by Vaccination with Multiple Recombinant Outer Membrane Proteins of Intracellular and Extracellular Virions
- Christiana N. Fogg, S. Lustig, J. C. Whitbeck, R. Eisenberg, G. Cohen, B. Moss
- BiologyJournal of Virology
- 1 October 2004
The feasibility of a multiprotein smallpox vaccine is suggested, with the best protection obtained with a vaccine made by combining recombinant proteins of the outer membranes of intracellular and extracellular virus.
Three classes of cell surface receptors for alphaherpesvirus entry.
The focus of this review is cell surface receptors forentry of alphaherpesvirus into cells, which are important targets of infection include cells of the mucosal epithelium and neurons, but are not limited to these celltypes.
Glycoprotein D of herpes simplex virus (HSV) binds directly to HVEM, a member of the tumor necrosis factor receptor superfamily and a mediator of HSV entry
HVEM interacts directly with gD, suggesting that HV EM is a receptor for virion gD and that the interaction between these proteins is a step in HSV entry into HVEM-expressing cells.
Herpes simplex virus glycoproteins gB and gH function in fusion between the virion envelope and the outer nuclear membrane
- A. Farnsworth, T. Wisner, David C. Johnson
- BiologyProceedings of the National Academy of Sciences
- 12 June 2007
It is concluded that either HSV gB or gH can promote fusion between the virion envelope and the outer NM, suggesting that the two types of fusion (egress versus entry) are dissimilar processes.