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The Expression of Vesicular Glutamate Transporters Defines Two Classes of Excitatory Synapse
The quantal release of glutamate depends on its transport into synaptic vesicles. Recent work has shown that a protein previously implicated in the uptake of inorganic phosphate across the plasmaExpand
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Identification and characterization of the vesicular GABA transporter
Synaptic transmission involves the regulated exocytosis of vesicles filled with neurotransmitter. Classical transmitters are synthesized in the cytoplasm, and so must be transported into synapticExpand
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Fatigue of long duration in human skeletal muscle after exercise.
1. After severe muscular contraction in man recovery of force is largely complete in a few minutes, but is not wholly so for many hours. The long‐lasting element of fatigue is found to occurExpand
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Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis
The protein alpha-synuclein accumulates in the brain of patients with sporadic Parkinson's disease (PD), and increased gene dosage causes a severe, dominantly inherited form of PD, but we know littleExpand
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Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors
Mechanical pain contributes to the morbidity associated with inflammation and trauma, but primary sensory neurons that convey the sensation of acute and persistent mechanical pain have not beenExpand
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Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter.
Previous work has identified two families of proteins that transport classical neurotransmitters into synaptic vesicles, but the protein responsible for vesicular transport of the principalExpand
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The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate
Quantal release of the principal excitatory neurotransmitter glutamate requires a mechanism for its transport into secretory vesicles. Within the brain, the complementary expression of vesicularExpand
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The Vesicular GABA Transporter, VGAT, Localizes to Synaptic Vesicles in Sets of Glycinergic as Well as GABAergic Neurons
A transporter thought to mediate accumulation of GABA into synaptic vesicles has recently been cloned (McIntire et al., 1997). This vesicular GABA transporter (VGAT), the first vesicular amino acidExpand
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The Neurotransmitter Cycle and Quantal Size
  • R. Edwards
  • Biology, Medicine
  • Neuron
  • 20 September 2007
Changes in the response to release of a single synaptic vesicle have generally been attributed to postsynaptic modification of receptor sensitivity, but considerable evidence now demonstrates thatExpand
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VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate
Exocytotic release of the excitatory neurotransmitter glutamate depends on transport of this amino acid into synaptic vesicles. Recent work has identified a distinct family of proteins responsibleExpand
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