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Identification and characterization of the vesicular GABA transporter
TLDR
A rat homologue of unc-47 is expressed by central GABA neurons and confers vesicular GABA transport in transfected cells with kinetics and substrate specificity similar to those previously reported for synaptic vesicles from the brain, and thus VGAT is the first of a new family of neurotransmitter transporters.
Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter.
TLDR
It is demonstrated that a protein that is unrelated to any known neurotransmitter transporters and that was previously suggested to mediate the Na(+)-dependent uptake of inorganic phosphate across the plasma membrane transports glutamate into synaptic vesicles.
Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors
TLDR
It is reported that a small subset of cells in the DRG expresses the low abundance vesicular glutamate transporter VGLUT3 (also known as SLC17A8), which impairs mechanical pain sensation and the mechanical hypersensitivity to normally innocuous stimuli that accompanies inflammation, nerve injury and trauma.
The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate
TLDR
The distribution and subcellular location of VGLUT3 suggest novel modes of signaling by glutamate, and the dendritic expression of V GLUT3 by particular neurons also indicates the potential for retrograde synaptic signaling.
The Vesicular GABA Transporter, VGAT, Localizes to Synaptic Vesicles in Sets of Glycinergic as Well as GABAergic Neurons
TLDR
This work uses antibodies specific for N- and C-terminal epitopes of VGAT to localize the protein in the rat CNS and shows that the protein specifically associates with synaptic vesicles, contributing to the inhibitory neurotransmission mediated by these two amino acids.
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