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GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks
TLDR
The GINS (go ichi ni san) complex allows the MCM (minichromosome maintenance) helicase to interact with key regulatory proteins in large replisome progression complexes (RPCs) that are assembled during initiation and disassembled at the end of S phase. Expand
A key role for Ctf4 in coupling the MCM2‐7 helicase to DNA polymerase α within the eukaryotic replisome
TLDR
It is shown that cells lacking both Ctf4 and Mrc1 experience chronic activation of the DNA damage checkpoint during chromosome replication and do not complete the cell cycle, indicating that coupling MCM2‐7 to replicative polymerases is an important feature of the regulation of chromosome replication in eukaryotes. Expand
Complete and Integrated Pyrene Degradation Pathway in Mycobacterium vanbaalenii PYR-1 Based on Systems Biology
TLDR
Analysis of pyrene metabolism in M. vanbaalenii PYR-1 indicates that this bacterium degrades pyrene to central intermediates through o-phthalate and the beta-ketoadipate pathway. Expand
Eukaryotic replisome components cooperate to process histones during chromosome replication.
TLDR
The data indicate that the eukaryotic replication and transcription machineries use analogous assemblies of multiple chaperones to preserve chromatin integrity. Expand
Inn1 couples contraction of the actomyosin ring to membrane ingression during cytokinesis in budding yeast
TLDR
The data indicate that recruitment of the C2 domain of Inn1 to the contractile actomyosin ring is crucial for ingression of the plasma membrane during cytokinesis in budding yeast. Expand
Molecular Cloning and Expression of Genes Encoding a Novel Dioxygenase Involved in Low- and High-Molecular-Weight Polycyclic Aromatic Hydrocarbon Degradation in Mycobacterium vanbaalenii PYR-1
TLDR
The upregulation of nidA3B3 in M. vanbaalenii PYR-1 induced by PAHs was confirmed by reverse transcription-PCR analysis and close similarities to the corresponding PAH ring-hydroxylating dioxygenases from Mycobacterium and Rhodococcus were revealed. Expand
A Polyomic Approach To Elucidate the Fluoranthene-Degradative Pathway in Mycobacterium vanbaalenii PYR-1
TLDR
Mycobacterium vanbaalenii PYR-1 is capable of degrading a wide range of high-molecular-weight polycyclic aromatic hydrocarbons (PAHs), including fluoranthene, and metabolic information with the genomic and proteomic results and proposed pathways for the degradation are integrated. Expand
SUMOylation of the GTPase Rac1 is required for optimal cell migration
TLDR
It is identified that the small ubiquitin-like modifier E3-ligase, PIAS3, interacts with Rac1 and is required for increased Rac activation and optimal cell migration in response to hepatocyte growth factor (HGF) signalling, and a role for SUMO in the regulation of cell migration and invasion is revealed. Expand
Genomic analysis of polycyclic aromatic hydrocarbon degradation in Mycobacterium vanbaalenii PYR-1
TLDR
A pathway in which HMW PAHs are degraded into the β-ketoadipate pathway through protocatechuate and then mineralized to CO2 via TCA cycle is proposed and identified 67 and 23 genes involved in PAH degradation and T CA cycle pathways, respectively, to be expressed as proteins. Expand
Relative Quantitative Comparisons of the Extracellular Protein Profiles of Staphylococcus aureus UAMS-1 and Its sarA, agr, and sarA agr Regulatory Mutants Using One-Dimensional Polyacrylamide Gel
TLDR
One-dimensional polyacrylamide gel electrophoresis followed by nanocapillary liquid chromatography coupled with mass spectrometry was used to analyze proteins isolated from Staphylococcus aureus UAMS-1 and provided a convenient and reliable way of identifying proteins and comparing their relative abundances. Expand
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