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Math1: an essential gene for the generation of inner ear hair cells.
The mammalian inner ear contains the cochlea and vestibular organs, which are responsible for hearing and balance, respectively. The epithelia of these sensory organs contain hair cells that functionExpand
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Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems.
BETA2/NeuroD1 is a bHLH transcription factor that is expressed during development in the mammalian pancreas and in many locations in the central and peripheral nervous systems. During inner earExpand
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Postnatal Development of Type I and Type II Hair Cells in the Mouse Utricle: Acquisition of Voltage-Gated Conductances and Differentiated Morphology
The type I and type II hair cells of mature amniote vestibular organs have been classified according to their afferent nerve terminals: calyx and bouton, respectively. Mature type I and type II cellsExpand
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Adaptation of mechanoelectrical transduction in hair cells of the bullfrog's sacculus
Adaptation in a vestibular organ, the bullfrog's sacculus, was studied in vivo and in vitro. In the in vivo experiments, the discharge of primary saccular neurons and the extracellular response ofExpand
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Molecular Microdomains in a Sensory Terminal, the Vestibular Calyx Ending
Many primary vestibular afferents form large cup-shaped postsynaptic terminals (calyces) that envelope the basolateral surfaces of type I hair cells. The calyceal terminals both respond to glutamateExpand
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A delayed rectifier conductance in type I hair cells of the mouse utricle.
1. Membrane currents of hair cells in acutely excised or cultured mouse utricles were recorded with the whole cell voltage-clamp method at temperatures between 23 and 36 degrees C. 2. Type I and IIExpand
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Inwardly rectifying currents of saccular hair cells from the leopard frog.
1. Inwardly rectifying currents were characterized in sensory hair cells isolated from the saccules of leopard frogs, using the whole cell configuration of the patch-clamp technique in voltage-clampExpand
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M-Like K+ Currents in Type I Hair Cells and Calyx Afferent Endings of the Developing Rat Utricle
Type I vestibular hair cells have large K+ currents that, like neuronal M currents, activate negative to resting potential and are modulatable. In rodents, these currents are acquired postnatally. InExpand
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Vestibular hair cells and afferents: two channels for head motion signals.
Vestibular epithelia of the inner ear detect head motions over a wide range of amplitudes and frequencies. In mammals, afferent nerve fibers from central and peripheral zones of vestibular epitheliaExpand
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Ion channels set spike timing regularity of mammalian vestibular afferent neurons.
In the mammalian vestibular nerve, some afferents have highly irregular interspike intervals and others have highly regular intervals. To investigate whether spike timing is determined by theExpand
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