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Calcium Binding, but Not a Calcium-Myristoyl Switch, Controls the Ability of Guanylyl Cyclase-activating Protein GCAP-2 to Regulate Photoreceptor Guanylyl Cyclase*
- E. Olshevskaya, R. E. Hughes, J. Hurley, A. Dizhoor
- Biology, Medicine
- The Journal of Biological Chemistry
- 30 May 1997
Guanylyl cyclase-activating protein 2 (GCAP-2) is a recoverin-like calcium-binding protein that regulates photoreceptor guanylyl cyclase (RetGC) (Dizhoor, A. M., and Hurley, J. B. (1996)J. Biol.… Expand
The Passage of Vitamin C across the Erythrocyte Membrane
Summary In all the species examined dehydroascorbic acid entered the erythrocyte considerably more rapidly than ascorbic acid (vitamin C). The uptake was pH‐dependent but did not appear to be… Expand
Calcium-dependent solvation of the myristoyl group of recoverin.
Recoverin is an N-myristoylated calcium-binding protein present in the photoreceptor cells of the mammalian retina. It is believed to function as a calcium sensor in visual signal transduction by… Expand
The dietary potential of the common nettle.
- R. E. Hughes, P. Ellery, T. Harry, V. Jenkins, E. Jones
- Biology, Medicine
- Journal of the science of food and agriculture
- 1 December 1980
A leaf protein concentrate prepared from the young leaves of the common nettle (Urtica dioica) failed to support normal growth in young rats; supplementation with methionine produced a protein… Expand
Flavonoids: some physiological and nutritional considerations.
The uptake of D-araboascorbic acid (D-isoascorbic acid) by guinea-pig tissues.
I. Guinea-pigs on a low, controlled intake of ascorbic acid (0.3 mg/Ioo g body-weight) were given daily an oral supplement of L-ascorbic acid (AA) or of D-isoascorbic acid (isoAA) (both 1.5 mg/Ioo g… Expand
Plasma and leukocyte ascorbic acid levels in the elderly.
- M. Burr, P. Elwood, D. J. Hole, R. J. Hurley, R. E. Hughes
- The American journal of clinical nutrition
- 1 February 1974
A survey of ascorbic acid blood levels was carried out in the elderly population of a South Wales town. Response rates of 88% for the men and 84% for the women were obtained, and 830 subjects were… Expand
Altered transcription in yeast expressing expanded polyglutamine
- R. E. Hughes, R. S. Lo, +4 authors S. Fields
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 30 October 2001
Expanded polyglutamine tracts are responsible for at least eight fatal neurodegenerative diseases. In mouse models, proteins with expanded polyglutamine cause transcriptional dysregulation before… Expand
The crystal and molecular structure of L-alanyl-L-alanine.
A relationship between ascorbic acid and threonic acid in guinea-pigs.
- M. Thomas, R. E. Hughes
- Chemistry, Medicine
- Food and chemical toxicology : an international…
- 1 August 1983
Threonic acid is a major breakdown product of ascorbic acid used as a food additive. When administered orally to guinea-pigs (100 mg/kg body weight) for periods of 4 or 28 days, it produced a… Expand