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The medial temporal lobe.
The medial temporal lobe includes a system of anatomically related structures that are essential for declarative memory (conscious memory for facts and events). The system consists of the hippocampal… Expand
Recognition memory and the medial temporal lobe: a new perspective
Recognition memory is widely viewed as consisting of two components, recollection and familiarity, which have been proposed to be dependent on the hippocampus and the adjacent perirhinal cortex,… Expand
Impaired Recognition Memory in Rats after Damage to the Hippocampus
Rats with radio-frequency or ibotenic acid lesions of the hippocampus and rats with radio-frequency lesions of the fornix were tested on the visual paired comparison task (VPC), a test of recognition… Expand
Classical conditioning and brain systems: the role of awareness.
Classical conditioning of the eye-blink response, perhaps the best studied example of associative learning in vertebrates, is relatively automatic and reflexive, and with the standard procedure… Expand
Hippocampectomy impairs the memory of recently, but not remotely, acquired trace eyeblink conditioned responses.
New Zealand male rabbits (Oryctolagus cuniculus) were trained on a trace eyeblink conditioning paradigm using a 250-ms tone conditioned stimulus, a 100-ms airpuff unconditioned stimulus, and a 500-ms… Expand
Impaired Recognition Memory in Monkeys after Damage Limited to the Hippocampal Region
- S. Zola, L. Squire, E. Teng, L. Stefanacci, E. Buffalo, R. E. Clark
- Medicine, Biology
- The Journal of Neuroscience
- 1 January 2000
Monkeys with lesions limited to the hippocampal region (the hippocampus proper, the dentate gyrus, and the subiculum) were impaired on two tasks of recognition memory: delayed nonmatching to sample… Expand
Spatial memory, recognition memory, and the hippocampus.
- N. Broadbent, L. Squire, R. E. Clark
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 5 October 2004
There is wide agreement that spatial memory is dependent on the integrity of the hippocampus, but the importance of the hippocampus for nonspatial tasks, including tasks of object recognition memory… Expand
Dissociation between the effects of damage to perirhinal cortex and area TE.
- E. Buffalo, S. Ramus, R. E. Clark, E. Teng, L. Squire, S. Zola
- Psychology, Medicine
- Learning & memory
- 1 November 1999
Perirhinal cortex and area TE are immediately adjacent to each other in the temporal lobe and reciprocally interconnected. These areas are thought to lie at the interface between visual perception… Expand
Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats.
New granule cells are born throughout life in the dentate gyrus of the hippocampal formation. Given the fundamental role of the hippocampus in processes underlying certain forms of learning and… Expand
Medial entorhinal cortex lesions only partially disrupt hippocampal place cells and hippocampus-dependent place memory.
- J. Hales, Magdalene I. Schlesiger, J. K. Leutgeb, L. Squire, S. Leutgeb, R. E. Clark
- Biology, Medicine
- Cell reports
- 6 November 2014
The entorhinal cortex provides the primary cortical projections to the hippocampus, a brain structure critical for memory. However, it remains unclear how the precise firing patterns of medial… Expand