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Epigenetic memory at malaria virulence genes
TLDR
Control of var gene transcription and antigenic variation is associated with a chromatin memory that includes methylation of histone H3 at lysine K9 as an epigenetic mark, and how gene transcription memory may affect the mechanism of pathogenesis and immune evasion is discussed.
Variable switching rates of malaria virulence genes are associated with chromosomal position
TLDR
In clonal parasite populations, expression of var genes located in the central regions of chromosomes is remarkably stable and that they rarely undergo transcriptional switches in the absence of selection, and there is no predetermined order of expression.
Use of fish parasite species richness indices in analyzing anthropogenically impacted coastal marine ecosystems
TLDR
The cumulative species curve model is used, originally developed for estimating the "true" parasite species richness of a given habitat as a function of increasing sample size, in the characterization of communities of differentially impacted coastal marine ecosystems.
Mechanisms underlying mutually exclusive expression of virulence genes by malaria parasites
TLDR
The results provide the first evidence, to the knowledge, supporting the existence of a postulated var‐specific, subnuclear expression site and reinforce the conclusion that var gene regulation is based on cooperative interactions between the two promoters of each var gene.
Mutually Exclusive Expression of Virulence Genes by Malaria Parasites Is Regulated Independently of Antigen Production
TLDR
Mutually exclusive expression in P. falciparum is therefore regulated exclusively at the level of transcription, and a functional PfEMP1 protein is not necessary for viability or for proper gene regulation in cultured parasites.
Antisense long noncoding RNAs regulate var gene activation in the malaria parasite Plasmodium falciparum
TLDR
It is shown that antisense long noncoding RNAs initiating from var introns are associated with the single active var gene at the time in the cell cycle when the single var upstream promoter is active and played a key role in regulating var gene activation and mutually exclusive expression.
Use of rDNA polymorphism for identification of Heterophyidae infecting freshwater fishes.
TLDR
The phylogenetic interrelationship among the newly sequenced species of Heterophyidae is outlined and for the first time the life cycle of Pygidiopsis genata is elucidated.
3D nuclear architecture reveals coupled cell cycle dynamics of chromatin and nuclear pores in the malaria parasite Plasmodium falciparum
TLDR
It is suggested that cyclic patterns in gene expression during parasite development correlate with gross changes in cellular and nuclear architecture, as well as a dynamic nuclear polarity during schizogony.
Strict Pairing of var Promoters and Introns Is Required for var Gene Silencing in the Malaria Parasite Plasmodium falciparum*
TLDR
Data indicate that intron/promoter pairing is responsible for silencing each individual var gene and that disruption of silencing of one gene does not affect the transcriptional activity of neighboring var promoters, suggesting that silencing is regulated at the level of individual genes rather than by assembly of silent chromatin throughout a chromosomal region.
Clinostomum complanatum and Clinostomum marginatum (Rudolphi, 1819) (Digenea: Clinostomidae) Are Separate Species Based on Differences in Ribosomal DNA
TLDR
A genetic assay was developed to differentiate between the great blue heron Ardea herodias and the little egret Egretta garzetta and to diagnose all life-history stages of trematodes in their diverse hosts.
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